Wimmer R, Kühl H, Röttger S, Schempp W
Institute of Human Genetics and Anthropology, University of Freiburg, Freiburg, Germany.
Cytogenet Genome Res. 2002;96(1-4):287-9. doi: 10.1159/000063021.
The human male specific expressed gene families CDY and DAZ are known to be repetitively clustered in the Y-specific region of the human Y chromosome. Comparative FISH-mapping of DNA clones specific for CDY and DAZ resulted in a Y-specific but diverse signal pattern within the non-recombining region of the Y-chromosomes of human and great apes. It can be concluded that the non-recombining part of the Y-chromosomes including CDY and DAZ, was exposed to species-specific amplifications, diversifications and rearrangements. Evolutionary fast fixation of any of these variations was possible as long as they did not interfere with male fertility.
已知人类雄性特异性表达基因家族CDY和DAZ在人类Y染色体的Y特异性区域中呈重复聚集。对CDY和DAZ特异的DNA克隆进行比较荧光原位杂交定位，结果显示在人类和大猩猩Y染色体的非重组区域内呈现出Y特异性但多样的信号模式。可以得出结论，包括CDY和DAZ在内的Y染色体非重组部分经历了物种特异性的扩增、多样化和重排。只要这些变异不干扰雄性生育能力，它们中的任何一种都有可能在进化过程中快速固定下来。
