Toder R, Zeitler S, Goodfellow P N, Schempp W
Institut für Humangenetik und Anthropologie, Universität Freiburg, Germany.
Chromosome Res. 1993 Jul;1(2):117-20. doi: 10.1007/BF00710034.
Cytogenetic studies of the primate Y chromosomes have suggested that extensive rearrangements have occurred during evolution of the great apes. We have used in situ hybridization to define these rearrangements at the molecular level. pHU-14, a probe including sequences from the sex determining gene SRY, hybridizes close to the early replicating pseudoautosomal segment in a telomeric or subtelomeric position of the Y chromosomes of all great apes. The low copy repeat detected by the probe Fr35-II is obviously included in Y chromosomal rearrangements during hominid evolution. These results, combined with previous studies, suggest that the Y chromosome in great apes has a conserved region including the pseudoautosomal region and the testis-determining region. The rest of the Y chromosome has undergone several rearrangements in the different great apes.
灵长类Y染色体的细胞遗传学研究表明，在大猩猩的进化过程中发生了广泛的重排。我们利用原位杂交在分子水平上确定这些重排。pHU-14是一种包含性别决定基因SRY序列的探针，它在所有大猩猩Y染色体的端粒或亚端粒位置，靠近早期复制的拟常染色体区段处杂交。探针Fr35-II检测到的低拷贝重复序列显然包含在人类进化过程中的Y染色体重排中。这些结果与先前的研究相结合，表明大猩猩的Y染色体有一个保守区域，包括拟常染色体区域和睾丸决定区域。Y染色体的其余部分在不同的大猩猩中经历了几次重排。
