Gläser B, Grützner F, Willmann U, Stanyon R, Arnold N, Taylor K, Rietschel W, Zeitler S, Toder R, Schempp W
Institute of Human Genetics and Anthropology, University of Freiburg, Germany.
Mamm Genome. 1998 Mar;9(3):226-31. doi: 10.1007/s003359900730.
The three human male specific expressed gene families DAZ, RBM, and TSPY are known to be repetitively clustered in the Y-specific region of the human Y Chromosome (Chr). RBM and TSPY are Y-specifically conserved in simians, whereas DAZ cannot be detected on the Y chromosomes of New World monkeys. The proximity of SRY to the pseudoautosomal region (PAR) is highly conserved and thus most effectively stabilizes the pseudoautosomal boundary on the Y (PABY) in simians. In contrast, the non-recombining part of the Y Chrs, including DAZ, RBM, and TSPY, was exposed to species-specific amplifications, diversifications, and rearrangements. Evolutionary fast fixation of any of these variations was possible as long as they did not interfere with male fertility.
已知人类男性特异性表达的三个基因家族DAZ、RBM和TSPY在人类Y染色体（Chr）的Y特异性区域中呈重复聚类。RBM和TSPY在猿猴中是Y特异性保守的，而在新大陆猴的Y染色体上则检测不到DAZ。SRY与假常染色体区域（PAR）的接近度高度保守，因此能最有效地稳定猿猴Y染色体上的假常染色体边界（PABY）。相比之下，Y染色体的非重组部分，包括DAZ、RBM和TSPY，经历了物种特异性的扩增、多样化和重排。只要这些变异不干扰雄性生育能力，它们中的任何一个都有可能在进化中快速固定下来。
