比利时孕妇单纯疱疹病毒2型血清流行病学研究。
Seroepidemiology of herpes simplex type 2 in pregnant women in Belgium.
作者信息
Bodéus M, Laffineur K, Kabamba-Mukadi B, Hubinont C, Bernard P, Goubau P
机构信息
Department of Microbiology, Unit of Virology, Université Catholique de Louvain, Brussels, Belgium.
出版信息
Sex Transm Dis. 2004 May;31(5):297-300. doi: 10.1097/01.olq.0000124454.51844.e7.
OBJECTIVE
The objective of this study was to study the prevalence of herpes simplex virus (HSV) type 2 in pregnant women in Belgium.
STUDY DESIGN
The serum of 1000 consecutive women was collected. HSV-1 and HSV-2 control sera were added to the study. HSV-2 antibodies were tested with the HerpeSelect 2 enzyme-linked immunosorbent assay (ELISA; Focus) based on the use of the recombinant gG-2 antigen.
RESULTS
The 21 HSV-2 control subjects were positive. Among the HSV-1 control subjects, 18 were negative and 4 were positive. Among the pregnant women, 80.3% were negative, 1.5% had equivocal results, and 18.2% were positive. No statistical difference was observed according to the origin (European or African) of the women.
CONCLUSIONS
The results obtained with the control sera indicate a high sensitivity of the Focus ELISA, as well as a capacity to discriminate between HSV-1/HSV-2 infection. The HSV-2 prevalence in the studied population raises the question of the possible benefit of a specific preventive program in pregnant women.
目的
本研究的目的是调查比利时孕妇中单纯疱疹病毒2型（HSV-2）的流行情况。
研究设计
收集了1000名连续孕妇的血清。向研究中加入了HSV-1和HSV-2对照血清。使用基于重组gG-2抗原的HerpeSelect 2酶联免疫吸附测定（ELISA；Focus公司）检测HSV-2抗体。
结果
21名HSV-2对照受试者呈阳性。在HSV-1对照受试者中，18名呈阴性，4名呈阳性。在孕妇中，80.3%呈阴性，1.5%结果不明确，18.2%呈阳性。未观察到根据孕妇来源（欧洲或非洲）的统计学差异。
结论
对照血清获得的结果表明Focus ELISA具有高灵敏度，以及区分HSV-1/HSV-2感染的能力。研究人群中HSV-2的流行率引发了针对孕妇实施特定预防计划可能带来益处的问题。
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