Larcombe I, Mott M, Hunt L
Institute of Child Health, UBHT Education Centre, Upper Maudlin Street, Bristol BS2 8AE, UK.
Br J Cancer. 2002 Nov 18;87(11):1204-9. doi: 10.1038/sj.bjc.6600632.
This cross-sectional study collected baseline data on the health behaviours of a large population of survivors of childhood cancer in the UK, aged 18-30 years, compared with those of sex- and age-matched controls. Data from 178 young adult survivors of childhood cancer, diagnosed and treated at Bristol Children's Hospital, 184 peers from the survivors' GP practices and 67 siblings were collected by postal questionnaire. Conditional logistic regression analysis showed that, for matched sets of survivors and controls, survivors of a variety of childhood cancers reported lower levels of alcohol consumption (P=0.005), lower levels of cigarette smoking (P=0.027) and lower levels of recreational drug use (P=0.001) than controls. Analysis of matched sets of survivors and siblings showed similar trends but no significant differences. A health behaviour index for each participant was constructed from the data collected on five key health behaviours which influence future health status. Comparison of the means for each case group showed that survivors of childhood cancer were leading healthier lives than controls or siblings. This finding was expressed most clearly as the difference in the means of the health behaviour index for each case group, derived from five health behaviours (one-way ANOVA, P<0.001).
这项横断面研究收集了英国大量18至30岁儿童癌症幸存者的健康行为基线数据，并与性别和年龄匹配的对照组进行了比较。通过邮政问卷收集了来自布里斯托尔儿童医院确诊并接受治疗的178名儿童癌症年轻成年幸存者、184名来自幸存者全科医生诊所的同龄人以及67名兄弟姐妹的数据。条件逻辑回归分析表明，对于配对的幸存者和对照组，各类儿童癌症的幸存者报告的酒精消费量较低（P=0.005）、吸烟量较低（P=0.027）以及娱乐性药物使用量较低（P=0.001）。对配对的幸存者和兄弟姐妹的分析显示出类似趋势，但无显著差异。根据收集到的影响未来健康状况的五种关键健康行为数据，为每位参与者构建了一个健康行为指数。各病例组均值的比较表明，儿童癌症幸存者的生活方式比对照组或兄弟姐妹更健康。这一发现最明显地表现为各病例组健康行为指数均值的差异，该指数源自五种健康行为（单因素方差分析，P<0.001）。
