Rinsky R A, Hornung R W, Silver S R, Tseng C Y
Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA.
Am J Ind Med. 2002 Dec;42(6):474-80. doi: 10.1002/ajim.10138.
Previous studies of a cohort of rubber hydrochloride workers indicated an association between benzene exposure and excess mortality from leukemia and multiple myeloma. To determine whether risks remain elevated with increasing time since plant shutdown, we extended follow-up from 1981 through 1996.
We evaluated risk using standardized mortality ratios (SMR) and generalized Cox proportional hazards regression models.
Five new leukemia cases were observed in benzene-exposed white males, but the summary SMR for this group declined from 3.37 (95% CI = 1.54-6.41) to 2.56 (95% CI = 1.43-4.22). In regression models, cumulative exposure was significantly associated with elevated relative risks for leukemia mortality. Four new multiple myeloma deaths occurred, three of which were in workers judged to be unexposed.
These findings reaffirm the leukemogenic effects of benzene exposure and suggest that excess risk diminishes with time.
先前对一组盐酸橡胶工人的研究表明，苯暴露与白血病和多发性骨髓瘤的超额死亡率之间存在关联。为了确定自工厂关闭以来，随着时间的推移风险是否仍然升高，我们将随访时间从1981年延长至1996年。
我们使用标准化死亡比（SMR）和广义Cox比例风险回归模型评估风险。
在接触苯的白人男性中观察到5例新的白血病病例，但该组的汇总SMR从3.37（95%CI = 1.54 - 6.41）降至2.56（95%CI = 1.43 - 4.22）。在回归模型中，累积暴露与白血病死亡率的相对风险升高显著相关。发生了4例新的多发性骨髓瘤死亡，其中3例发生在被判定未接触的工人中。
这些发现再次证实了苯暴露的致白血病作用，并表明超额风险会随着时间而降低。
