Petruskevicius Juozas, Nielsen Strange, Kaalund Søren, Knudsen Preben R, Overgaard Søren
Department of Orthopaedics, Randers County Hospital, Denmark.
Acta Orthop Scand. 2002 Oct;73(5):575-8. doi: 10.1080/000164702321022875.
We studied the effects of a newly marketed bone substitute, Osteoset, on bone healing in a tibial defect in humans. 20 patients undergoing an ACL (anterior cruciate ligament) reconstruction with bone-patella tendon-bone graft were block-randomized into 2 groups of 10 each. In the treatment group, the tibial defect was filled manually with Osteoset pellets, in the control group the defect was left empty. CTs of the defect were taken on the first day after the operation, 6 weeks, 3 and 6 months postoperatively. We found about the same amount of bone in the defect in the Osteoset and control groups after 6 weeks, 3, and 6 months. In the control group, but not in the Osteoset group, the bone volume increased from 6 weeks to 3 months. The Osteoset pellets were almost resorbed after 6 weeks.
我们研究了一种新上市的骨替代物Osteoset对人类胫骨缺损骨愈合的影响。20例行前交叉韧带（ACL）重建并采用骨-髌腱-骨移植物的患者被区组随机分为两组，每组10人。治疗组中，胫骨缺损处手动填入Osteoset颗粒，对照组缺损处则保持空置。术后第1天、6周、3个月和6个月对缺损处进行CT扫描。我们发现，6周、3个月和6个月后，Osteoset组和对照组缺损处的骨量大致相同。在对照组中，骨体积从6周增加到3个月，但Osteoset组未出现这种情况。6周后Osteoset颗粒几乎被吸收。
