Mroueh A M, Seoud M A F, Kaspar H G, Zalloua P A
The American University of Beirut-Medical Center, Department of Obstetrics and Gynecology, Lebanon.
Eur J Gynaecol Oncol. 2002;23(5):429-32.
The purpose of this study was to determine the prevalence of human papillomavirus (HPV), and more specifically of HPV 16, in a group of Lebanese women.
Type-specific prevalence of cervical HPV and the presence of cytological abnormalities were determined in a cohort of Lebanese women. The population included 1,026 women, 18-76 years, seeking routine gynecological care at a tertiary care center. Demographic and behavioral data were collected. HPV DNA was detected in cervical scrapes by polymerase chain reaction using consensus primers. Cervical cytological abnormalities were identified by Papanicoleau (Pap) smears.
The mean age of our population was 40 +/- 11.3 years. General HPV DNA was detected in 50 patients (4.9%). The high-risk HPV type 16 DNA was detected in 31 patients (3%). Patients with HPV 16 were more likely to have an abnormal pap smear than those with negative tests (6.6% vs 1.6%, p < 0.05), and more likely, but not significantly, to be smokers (21.4% vs 18.4%, p = 0.5). The age-specific prevalence of HPV increased with age and peaked at 60-69 years.
The prevalence of HPV in this small group of Lebanese women is similar to its prevalence in the Mediterranean countries. The presence of HPV, its known association with the development of cervical neoplasia, and the lack of a universal screening program for cervical cancer in our country should be used to enforce implementation of proper screening programs.
本研究旨在确定一组黎巴嫩女性中人类乳头瘤病毒（HPV），尤其是HPV 16型的流行情况。
在一组黎巴嫩女性队列中确定宫颈HPV的型特异性流行情况以及细胞学异常的存在情况。该人群包括1026名年龄在18至76岁之间、在一家三级护理中心寻求常规妇科护理的女性。收集了人口统计学和行为学数据。使用通用引物通过聚合酶链反应在宫颈刮片中检测HPV DNA。通过巴氏涂片法识别宫颈细胞学异常。
我们研究人群的平均年龄为40±11.3岁。50名患者（4.9%）检测到一般HPV DNA。31名患者（3%）检测到高危HPV 16型DNA。HPV 16阳性患者的巴氏涂片异常的可能性高于检测结果为阴性的患者（6.6%对1.6%，p<0.05），且吸烟的可能性更高，但差异不显著（21.4%对18.4%，p = 0.5）。HPV的年龄特异性流行率随年龄增加而上升，并在60至69岁达到峰值。
这一小群黎巴嫩女性中HPV的流行率与地中海国家的流行率相似。HPV的存在、其与宫颈肿瘤发生的已知关联以及我国缺乏宫颈癌普遍筛查项目，应被用于推动实施适当的筛查项目。
