恶性疟原虫毒力决定因素被揭示。
Plasmodium falciparum virulence determinants unveiled.
作者信息
Crabb Brendan S, Cowman Alan F
机构信息
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
出版信息
Genome Biol. 2002 Oct 25;3(11):REVIEWS1031. doi: 10.1186/gb-2002-3-11-reviews1031.
Abstract
The human malaria parasite Plasmodium falciparum, one of the world's most devastating pathogens, has an astonishing array of sequences and genes that play key roles in pathogenesis and immune evasion. We must understand the functions of these elements if the chronicity and unpredictable virulence of Plasmodium is to be explained.
摘要
人类疟原虫恶性疟原虫是世界上最具毁灭性的病原体之一，它拥有一系列数量惊人的序列和基因，这些序列和基因在发病机制和免疫逃避中发挥着关键作用。如果要解释疟原虫的慢性病程和不可预测的毒力，我们就必须了解这些元件的功能。
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