Vigan M, Girardin P, Desprez P, Adessi B, Aubin F, Laurent R
UF Allergologie, Hôpital Saint Jacques, Dermatologie 2, Besançon, France.
Ann Dermatol Venereol. 2002 Oct;129(10 Pt 1):1125-7.
Photoallergy to ketoprofen and cross reactivity of ketoprofen with diphenylketones are well known; here are some cases of photoreaction to ketoprofen and unusual substances.
Eleven photoallergic to ketoprofen patients were photo patch tested with Ketum(R), ketoprofen, oxybenzone, tiaprofenic acid, fenofibrate, and also chlorphenesin, sunscreen series, and photobiologists series (without lichen mix and benzocaine). We performed tests at day 0, we irradiated them with UVA at day 2, and control series remained closed. We performed readings at day 3 and 4 according to ICDRG's recommendations.
Nine tested patients had positive reactions to the irradiated tests with no expected allergens: fenticlor (9 cases), halogenated salicylanilides (4 cases), dibenzoylmethane (3 cases) and cinnamate (1 case).
The mechanism of these unusual photosensitizations is discussed. These cases show that it is important to test sunscreen series and photobiologists series in patients photoallergic to ketoprofen.
酮洛芬的光过敏反应以及酮洛芬与二苯甲酮的交叉反应已广为人知；以下是一些对酮洛芬及其他异常物质的光反应病例。
对11名对酮洛芬光过敏的患者进行光斑贴试验，使用的物质有Keturum®、酮洛芬、氧苯酮、噻洛芬酸、非诺贝特，还有氯苯甘醚、防晒系列产品以及光生物学系列产品（不含地衣混合物和苯佐卡因）。我们在第0天进行试验，在第2天用UVA照射，对照系列保持封闭状态。我们根据国际接触性皮炎研究组（ICDRG）的建议在第3天和第4天进行读数。
9名受试患者对经照射试验中的非预期变应原产生阳性反应：芬替克洛（9例）、卤化水杨酰苯胺（4例）、二苯甲酰甲烷（3例）和肉桂酸盐（1例）。
对这些异常光致敏反应的机制进行了讨论。这些病例表明，对酮洛芬光过敏的患者进行防晒系列产品和光生物学系列产品的检测很重要。
