Jeanmougin M, Petit A, Manciet J R, Sigal M, Dubertret L
Unité de Photodermatologie, Hôpital Saint-Louis, Paris.
Ann Dermatol Venereol. 1996;123(4):251-5.
Since 1983, several cases of allergy and photoallergic contact dermatitis to ketoprofen gel have been reported in Italy and Spain. In France, this drug has been available for topic applications since 1989 and no cases of photoallergy have been reported.
We observed two cases of photoallergic contact dermatitis to ketoprofen (Profenid gel, Ketum gel). Imputability was suggested by clinical history and proven by patch-tests showing evidence of crossed photoallergy with fenofibrate in both cases. Photoallergic dermatitis to oxybenzone was associated in one case.
Ketoprofen is the predominant nonsteroid anti-inflammatory drug responsible for allergic and/or photoallergic contact dermatitis resulting from topic applications. Its prevalence is probably underestimated in France in light of the number of cases reported in certain Mediterranean countries. Cross reactive photoallergy to ketoprofen and fenofibrate can be explained by the common benzoly-ketone structure of these compounds. In case of skin reaction, the other drug should not be prescribed and benzophenone-containing cosmetics discouraged.
自1983年以来，意大利和西班牙已报告了数例对酮洛芬凝胶的过敏和光过敏性接触性皮炎病例。在法国，自1989年起该药物可用于局部应用，尚未报告光过敏病例。
我们观察到两例对酮洛芬（普洛芬凝胶、凯通凝胶）的光过敏性接触性皮炎。临床病史提示了病因，斑贴试验证实了病因，两例均显示与非诺贝特存在交叉光过敏证据。其中一例还伴有对氧苯酮的光过敏性皮炎。
酮洛芬是导致局部应用引起过敏和/或光过敏性接触性皮炎的主要非甾体抗炎药。鉴于某些地中海国家报告的病例数量，其在法国的患病率可能被低估。酮洛芬与非诺贝特的交叉反应性光过敏可通过这些化合物共有的苯甲酰酮结构来解释。发生皮肤反应时，不应开具另一种药物，并应劝阻使用含二苯甲酮的化妆品。
