骨髓中淋巴细胞生成的发展图景。
A developing picture of lymphopoiesis in bone marrow.
作者信息
Hirose Jun, Kouro Taku, Igarashi Hideya, Yokota Takafumi, Sakaguchi Nobuo, Kincade Paul W
机构信息
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
出版信息
Immunol Rev. 2002 Nov;189:28-40. doi: 10.1034/j.1600-065x.2002.18904.x.
Abstract
The earliest progenitors of lymphocytes are extremely rare and typically present among very complex populations of hematopoietic cells. Additionally, it is difficult to know how cells with any given set of characteristics are developmentally related to stem cells and maturing lymphoid precursors. However, it is now possible to divide bone marrow into progressively smaller fractions and exploit well-defined culture systems to determine which ones contain cells that can turn into lymphocytes. Analysis of steroid hormone sensitive cells and use of two-step cultures is providing additional information about the most likely differentiation pathways for B and natural killer cell lineage lymphocytes. A newly identified category of early lymphoid progenitors can now be sorted to high purity from RAG1/GFP knock in mice. Furthermore, the same experimental model makes it possible to image lymphoid progenitors in fetal and adult hematopoietic tissues.
摘要
淋巴细胞的最早祖细胞极为罕见，通常存在于非常复杂的造血细胞群体中。此外，很难知道具有任何给定特征集的细胞在发育上如何与干细胞和成熟的淋巴细胞前体相关。然而，现在可以将骨髓逐步分成更小的部分，并利用定义明确的培养系统来确定哪些部分含有能够转化为淋巴细胞的细胞。对类固醇激素敏感细胞的分析以及两步培养的使用，正在提供有关B细胞和自然杀伤细胞谱系淋巴细胞最可能的分化途径的更多信息。现在可以从RAG1/GFP基因敲入小鼠中以高纯度分选新鉴定的早期淋巴细胞祖细胞类别。此外，相同的实验模型使得对胎儿和成人造血组织中的淋巴细胞祖细胞进行成像成为可能。
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