Emsley Hedley C A, Molloy Jane
University of Manchester and Hope Hospital, Salford, UK.
Clin Neurol Neurosurg. 2002 Dec;105(1):23-6. doi: 10.1016/s0303-8467(02)00087-2.
A 66-year-old man with secondary progressive multiple sclerosis presented with a flaccid areflexic tetraparesis evolving over a 6-week period. Clinical examination and subsequent investigation confirmed a diagnosis of sub-acute inflammatory demyelinating polyradiculoneuropathy (sub-acute IDP). Nephrotic-range proteinuria and thrombocytopaenia were also noted at the time of presentation-histopathological investigation of the former showed membranous glomerulonephritis as the basis for the protein loss. The IDP, glomerulonephritis and thrombocytopaenia recovered over the same time course. There have been previous reports of either glomerulonephritis or thrombocytopaenia occurring in association with IDP-there are no such reports of all three conditions occurring and resolving simultaneously.
一名66岁患有继发性进行性多发性硬化症的男性患者，出现弛缓性无反射性四肢轻瘫，病程长达6周。临床检查及后续调查确诊为亚急性炎症性脱髓鞘性多发性神经根神经病（亚急性IDP）。就诊时还发现有肾病范围的蛋白尿和血小板减少症，前者的组织病理学检查显示膜性肾小球肾炎是蛋白质丢失的原因。IDP、肾小球肾炎和血小板减少症在同一病程中恢复。此前曾有关于肾小球肾炎或血小板减少症与IDP相关的报道，但没有这三种情况同时发生并同时缓解的报道。
