与吉兰-巴雷综合征相关的继发性膜性肾病。
Secondary membranous nephropathy associated with guillain-barré syndrome.
作者信息
Filippone Edward J, Kanzaria Mitul, Bell Rodney, Newman Eric, L Farber John
机构信息
Department of Medicine, Thomas Jefferson University, Philadelphia, Pa., USA ; Division of Nephrology, Thomas Jefferson University, Philadelphia, Pa., USA.
出版信息
Case Rep Nephrol Urol. 2013 Apr 10;3(1):34-9. doi: 10.1159/000350903. Print 2013 Jan.
Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome (NS) in adults. It may be primary, usually mediated by IgG4 anti-phospholipase A2 autoantibodies or secondary to various other conditions. Guillain- Barré syndrome (GBS) has been associated with MN, but a cause and effect relation has not been proven. We present a case of concurrent development of GBS and severe NS, with renal biopsy demonstrating MN. IgG4 stain was negative, indicating that most likely, the MN was secondary and probably caused by the underlying GBS.
膜性肾病（MN）是成人肾病综合征（NS）最常见的病因之一。它可能是原发性的，通常由IgG4抗磷脂酶A2自身抗体介导，或继发于各种其他病症。吉兰 - 巴雷综合征（GBS）与MN有关，但因果关系尚未得到证实。我们报告一例同时发生GBS和严重NS的病例，肾活检显示为MN。IgG4染色为阴性，表明MN很可能是继发性的，可能由潜在的GBS引起。
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