Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: historical cohort study.

OBJECTIVES

An association between use of cannabis in adolescence and subsequent risk of schizophrenia was previously reported in a follow up of Swedish conscripts. Arguments were raised that this association may be due to use of drugs other than cannabis and that personality traits may have confounded results. We performed a further analysis of this cohort to address these uncertainties while extending the follow up period to identify additional cases.

DESIGN

Historical cohort study.

SETTING

1969-70 survey of Swedish conscripts (>97% of the country's male population aged 18-20).

PARTICIPANTS

50 087 subjects: data were available on self reported use of cannabis and other drugs, and on several social and psychological characteristics.

MAIN OUTCOME MEASURES

Admissions to hospital for ICD-8/9 schizophrenia and other psychoses, as determined by record linkage.

RESULTS

Cannabis was associated with an increased risk of developing schizophrenia in a dose dependent fashion both for subjects who had ever used cannabis (adjusted odds ratio for linear trend of increasing frequency 1.2, 95% confidence interval 1.1 to 1.4, P<0.001), and for subjects who had used only cannabis and no other drugs (adjusted odds ratio for linear trend 1.3, 1.1 to 1.5, P<0.015). The adjusted odds ratio for using cannabis >50 times was 6.7 (2.1 to 21.7) in the cannabis only group. Similar results were obtained when analysis was restricted to subjects developing schizophrenia after five years after conscription, to exclude prodromal cases.

CONCLUSIONS

Cannabis use is associated with an increased risk of developing schizophrenia, consistent with a causal relation. This association is not explained by use of other psychoactive drugs or personality traits relating to social integration.