Chen Honglei, Zhang Shumin M, Hernán Miguel A, Willett Walter C, Ascherio Alberto
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Ann Neurol. 2002 Dec;52(6):793-801. doi: 10.1002/ana.10381.
Diet may play a causative role in Parkinson's disease (PD), but potential associations between diet and PD risk rarely have been assessed in prospective studies. We investigated associations between food intakes and PD risk in two large prospective cohorts in which 210 incident PD cases in men and 184 in women were documented. A positive association was found between dairy intake and PD risk in men (relative risk [RR] comparing extreme categories, 1.8; p trend = 0.004), but not in women (RR, 1.1; p trend = 0.9). No other food groups were associated with PD risk in either men or women. Further analyses among men showed significant positive associations with PD risk for intakes of several dairy foods as well as dairy calcium (RR, 1.5; p trend = 0.02), dairy vitamin D (RR, 1.6; p trend = 0.004), dairy protein (RR, 1.6; p trend = 0.01), and lactose (RR, 1.8; p trend = 0.002), but not dairy fat (RR, 1.1; p trend = 0.4). Intakes of calcium, vitamin D, and protein from other dietary or supplemental sources were not related to PD risk in men. Our results suggest that higher intake of dairy products may increase the risk of PD in men; however, this finding needs further evaluation, and the underlying active components need to be identified.
饮食可能在帕金森病（PD）中起致病作用，但饮食与PD风险之间的潜在关联在前瞻性研究中很少被评估。我们在两个大型前瞻性队列中调查了食物摄入量与PD风险之间的关联，其中记录了210例男性新发PD病例和184例女性新发PD病例。在男性中发现乳制品摄入量与PD风险呈正相关（比较极端分类的相对风险[RR]为1.8；趋势p值=0.004），但在女性中未发现（RR为1.1；趋势p值=0.9）。在男性或女性中，没有其他食物组与PD风险相关。对男性的进一步分析显示，几种乳制品以及乳制品钙（RR为1.5；趋势p值=0.02）、乳制品维生素D（RR为1.6；趋势p值=0.004）、乳制品蛋白质（RR为1.6；趋势p值=0.01）和乳糖（RR为1.8；趋势p值=0.002）的摄入量与PD风险呈显著正相关，但乳制品脂肪（RR为1.1；趋势p值=0.4）与PD风险无关。来自其他饮食或补充来源的钙、维生素D和蛋白质的摄入量与男性的PD风险无关。我们的结果表明，较高的乳制品摄入量可能会增加男性患PD的风险；然而，这一发现需要进一步评估，并且需要确定潜在的活性成分。
