Romanova Nadya, Favrin Stacy, Griffiths Mansel W
Canadian Research Institute for Food Safety, University of Guelph, Ontario, Canada N1G 2W1.
Appl Environ Microbiol. 2002 Dec;68(12):6405-9. doi: 10.1128/AEM.68.12.6405-6409.2002.
Nineteen Listeria monocytogenes strains were characterized by automated ribotyping, pulsed-field gel electrophoresis, and plasmid profiling to determine the relationship between genotype and sanitizer resistance. Isolates within a ribogroup had a consistent sensitivity or resistance phenotype except for ribogroup C isolates. All isolates with resistance phenotypes harbored two plasmids. The sensitivity of L. monocytogenes strains to quaternary ammonium compounds (QACs) was correlated with sensitivity to sanitizers and antibiotics with other modes of action. All isolates tested contained the mdrL gene, which encodes an efflux pump that confers resistance to QACs and is both chromosome and plasmid borne.
对19株单核细胞增生李斯特菌菌株进行了自动核糖体分型、脉冲场凝胶电泳和质粒图谱分析，以确定基因型与消毒剂抗性之间的关系。除了核糖体分型C组的分离株外，同一核糖体分型组内的分离株具有一致的敏感或抗性表型。所有具有抗性表型的分离株都携带两个质粒。单核细胞增生李斯特菌菌株对季铵化合物（QACs）的敏感性与对其他作用方式的消毒剂和抗生素的敏感性相关。所有测试的分离株都含有mdrL基因，该基因编码一种外排泵，赋予对QACs的抗性，且该基因同时存在于染色体和质粒上。
