Fudge Julie L, Haber Suzanne N
Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA.
J Neurosci. 2002 Dec 1;22(23):10078-82. doi: 10.1523/JNEUROSCI.22-23-10078.2002.
Afferents from the amygdala help to define the ventral striatum and mediate goal-directed behaviors. In addition to well known inputs to the classic ventral striatum, the amygdala also projects to the caudoventral striatum and amygdalostriatal area. We examined whether the primate caudoventral striatum and amygdalostriatal area can be considered part of the "ventral" striatum based on cellular and histochemical features found in the classic rostral ventral striatum. We used several histochemical stains, including calbindin-D28k, a marker of the shell compartment, acetylcholinesterase, substance P, tyrosine hydroxylase, and Bcl-2, a marker of immature neurons, to examine this question. Our results indicate that the lateral amygdalostriatal area and caudoventral striatum are "striatal like" based on intermediate to high acetylcholinesterase and tyrosine hydroxylase levels. The lateral amygdalostriatal area is chemically similar to the shell, whereas the caudoventral striatum more closely resembles the striatum outside the shell. In contrast, the medial amygdalostriatal area is more related to the central amygdaloid nucleus than to the striatum. Bcl-2 immunoreactivity is associated with granular islands and medium-sized cells in the vicinity of the ventral striatum both rostrally and caudally. Together, the caudal ventral striatum has a histochemical and cellular organization similar to that of the rostral ventral striatum, consistent with their common innervation by the amygdala and other ventral structures. In addition, Bcl-2 is expressed in and near both poles of the ventral striatum, suggesting that these areas maintain a heightened capacity for growth and plasticity compared with other striatal sectors.
来自杏仁核的传入神经有助于界定腹侧纹状体并介导目标导向行为。除了对经典腹侧纹状体的已知输入外，杏仁核还投射到尾腹侧纹状体和杏仁核纹状体区域。我们根据在经典吻侧腹侧纹状体中发现的细胞和组织化学特征，研究了灵长类动物的尾腹侧纹状体和杏仁核纹状体区域是否可被视为“腹侧”纹状体的一部分。我们使用了几种组织化学染色方法，包括钙结合蛋白-D28k（壳区室的标志物）、乙酰胆碱酯酶、P物质、酪氨酸羟化酶以及Bcl-2（未成熟神经元的标志物）来研究这个问题。我们的结果表明，基于中到高乙酰胆碱酯酶和酪氨酸羟化酶水平，外侧杏仁核纹状体区域和尾腹侧纹状体具有“纹状体样”特征。外侧杏仁核纹状体区域在化学性质上与壳区相似，而尾腹侧纹状体更类似于壳区以外的纹状体。相比之下，内侧杏仁核纹状体区域与中央杏仁核的关系比与纹状体的关系更密切。Bcl-2免疫反应性与吻侧和尾侧腹侧纹状体附近的颗粒岛和中型细胞相关。总之，尾侧腹侧纹状体具有与吻侧腹侧纹状体相似的组织化学和细胞组织，这与它们由杏仁核和其他腹侧结构共同支配相一致。此外，Bcl-2在腹侧纹状体的两极及其附近表达，这表明与其他纹状体区域相比，这些区域保持着更高的生长和可塑性能力。
