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（2-羟基丁基）-正丁基亚硝胺的大鼠尿液代谢产物

[Rat urinary metabolites of (2-hydroxybutyl)-n-butylnitrosamine].

作者信息

Blattmann L, Preussmann R

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975;83(2):125-7. doi: 10.1007/BF00282979.

DOI:10.1007/BF00282979
PMID:124517
Abstract

The chemical structure of 3 urinary metabolites of 2-hydroxy-di-n-butylnitrosamine has been identified by mass spectrometry. The results indicate that oxidation and formation of metabolites with shorter chain length may be explained by alpha-oxidation and subsequent degradation. This is an alternative to the beta-oxidation hypothesis of Krüger (1971).

摘要

通过质谱分析法已鉴定出2-羟基-二正丁基亚硝胺的3种尿液代谢物的化学结构。结果表明，具有较短链长度的代谢物的氧化和形成可能可用α-氧化及随后的降解来解释。这是对Krüger（1971年）的β-氧化假说的一种替代。

相似文献

1
[Rat urinary metabolites of (2-hydroxybutyl)-n-butylnitrosamine].（2-羟基丁基）-正丁基亚硝胺的大鼠尿液代谢产物
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975;83(2):125-7. doi: 10.1007/BF00282979.
2
Direct alkyl chain cleavage after C-hydroxylation of dialkylnitrosamines in rats. A new pathway of the oxidative biotransformation.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):315-22. doi: 10.1007/BF00305369.
3
[Structure of rat urinary metabolites of the carcinogen methyl-n-butyl-nitrosamine (author's transl)].
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974 Mar 14;81(1):71-3. doi: 10.1007/BF00303602.
4
Metabolic fate and carcinogenicity of N-(omega-hydroxyalkyl) N-(4-hydroxybutyl) nitrosamines analogs of N-butyl-N-(4-hydroxy-butyl) nitrosamine, in the rat.大鼠体内N-丁基-N-（4-羟丁基）亚硝胺的N-（ω-羟烷基）N-（4-羟丁基）亚硝胺类似物的代谢命运和致癌性
Gan. 1981 Aug;72(4):539-46.
5
Oxidative biotransformation of di-n-butylnitrosamine. Formation in vitro of aldehydes in the presence of rat liver microsomes.二正丁基亚硝胺的氧化生物转化。在大鼠肝微粒体存在的情况下醛类在体外的形成。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):311-4. doi: 10.1007/BF00305368.
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Metabolic fate of N-butyl-N-(4-hydroxybutyl)nitrosamine homologs in the rat, in relation to their organotropic carcinogenicity to the urinary bladder.大鼠体内 N-丁基-N-(4-羟基丁基)亚硝胺同系物的代谢命运，及其对膀胱的器官特异性致癌性
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Metabolic fate of N-alkyl-N-(3-hydroxypropyl and 2-hydroxy-ethyl)nitrosamines in the rat in relation to the induction of bladder cancer by N-butyl-N-(4-hydroxybutyl)nitrosamine and its homologs.大鼠体内N-烷基-N-(3-羟丙基和2-羟乙基)亚硝胺的代谢命运与N-丁基-N-(4-羟丁基)亚硝胺及其同系物诱发膀胱癌的关系。
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[Biotransformation of carcinogenic dialkylnitrosamines. Further urinary metabolites of di-n-butyl- and di-n-pentyl-nitrosamine (author's transl)].[致癌二烷基亚硝胺的生物转化。二正丁基和二正戊基亚硝胺的进一步尿代谢产物（作者译）]
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Metabolic fate of N-n-butyl-N-(4-hydroxybutyl)-nitrosamine and its analogues. Selective induction of urinary bladder tumours in the rat.
Xenobiotica. 1977 Jan-Feb;7(1-2):11-24. doi: 10.3109/00498257709036241.
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引用本文的文献

1
Letter: Induction of tumours and bifunctional crosslinking metabolites of nitrosamines.信件：亚硝胺诱导肿瘤及双功能交联代谢产物
Br J Cancer. 1976 Jun;33(6):668-9. doi: 10.1038/bjc.1976.106.
2
Direct alkyl chain cleavage after C-hydroxylation of dialkylnitrosamines in rats. A new pathway of the oxidative biotransformation.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):315-22. doi: 10.1007/BF00305369.
3
Oxidative biotransformation of di-n-butylnitrosamine. Formation in vitro of aldehydes in the presence of rat liver microsomes.二正丁基亚硝胺的氧化生物转化。在大鼠肝微粒体存在的情况下醛类在体外的形成。

本文引用的文献

1
Alkylation of rat liver RNA by cyclic N-nitrosamines in vivo.体内环状N-亚硝胺对大鼠肝脏RNA的烷基化作用。
J Natl Cancer Inst. 1966 Oct;37(4):401-7.
2
Alkylation of rat liver nucleic acids not related to carcinogenesis by N-nitrosamines.
J Natl Cancer Inst. 1969 Jun;42(6):1095-100.
3
Metabolism of butyl(4-hydroxybutyl)nitrosoamine in rats.
Gan. 1972 Jun;63(3):391-2.
4
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):311-4. doi: 10.1007/BF00305368.
Metabolism of nitrosamines in vivo. II. On the methylation of nucleic acids by aliphatic di-n-alkyl-nitrosamines in vivo, caused by beta-oxydation: the increased formation of 7-methyl-guanine after application of beta-hydroxypropyl-propyl-nitrosamine compared to that after application of di-n-propyl-nitrosamine.
亚硝胺的体内代谢。II. 关于体内脂肪族二正烷基亚硝胺通过β-氧化作用导致核酸甲基化的研究：与应用二正丙基亚硝胺后相比，应用β-羟丙基-丙基亚硝胺后7-甲基鸟嘌呤的生成增加。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(2):90-7. doi: 10.1007/BF00284383.
5
[Structure of rat urinary metabolites of carcinogenic dialkylnitrosamines (author's transl)].[致癌二烷基亚硝胺的大鼠尿液代谢物结构（作者译）]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(1):3-5. doi: 10.1007/BF00284333.
6
[Biotransformation of carcinogenic dialkylnitrosamines. Further urinary metabolites of di-n-butyl- and di-n-pentyl-nitrosamine (author's transl)].[致癌二烷基亚硝胺的生物转化。二正丁基和二正戊基亚硝胺的进一步尿代谢产物（作者译）]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974 Mar 14;81(1):75-8. doi: 10.1007/BF00303603.
7
[Structure of rat urinary metabolites of the carcinogen methyl-n-butyl-nitrosamine (author's transl)].
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974 Mar 14;81(1):71-3. doi: 10.1007/BF00303602.
8
Metabolism of nitrosamines in vivo. 3. On the methylation of nucleic acids by aliphatic Di-n-alkyl-nitrosamines in vivo resueting from heta-oxidation: the formation of 7-methylguanine after application of 2-oxo-propyl-propyl-nitrosamine and methyl-propyl-nitro-samine.亚硝胺的体内代谢。3. 关于体内由β-氧化产生的脂肪族二正烷基亚硝胺对核酸的甲基化作用：应用2-氧代丙基丙基亚硝胺和甲基丙基亚硝胺后7-甲基鸟嘌呤的形成。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973 Dec 6;80(3):189-96. doi: 10.1007/BF00284318.
9
[Metabolism of nitrosamines in vivo. I. Evidence for -oxydation of aliphatic di-n-alkylnitrosamines: the stimultaneous formation of 7-methylguanine besides 7-propyl- or 7-butylguanine after application of di-n-propyl- or di-n-butylnitrosamine].[体内亚硝胺的代谢。I. 脂肪族二正烷基亚硝胺α-氧化的证据：在应用二正丙基或二正丁基亚硝胺后，除了7-丙基或7-丁基鸟嘌呤外，同时形成7-甲基鸟嘌呤]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1971;76(2):145-54. doi: 10.1007/BF00284425.