[体内亚硝胺的代谢。I. 脂肪族二正烷基亚硝胺α-氧化的证据：在应用二正丙基或二正丁基亚硝胺后，除了7-丙基或7-丁基鸟嘌呤外，同时形成7-甲基鸟嘌呤] - Suppr

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超能文献

[Metabolism of nitrosamines in vivo. I. Evidence for -oxydation of aliphatic di-n-alkylnitrosamines: the stimultaneous formation of 7-methylguanine besides 7-propyl- or 7-butylguanine after application of di-n-propyl- or di-n-butylnitrosamine].

作者信息

Krüger F W

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1971;76(2):145-54. doi: 10.1007/BF00284425.

DOI:10.1007/BF00284425

PMID:4255598

Abstract

摘要

相似文献

[Metabolism of nitrosamines in vivo. I. Evidence for -oxydation of aliphatic di-n-alkylnitrosamines: the stimultaneous formation of 7-methylguanine besides 7-propyl- or 7-butylguanine after application of di-n-propyl- or di-n-butylnitrosamine].[体内亚硝胺的代谢。I. 脂肪族二正烷基亚硝胺α-氧化的证据：在应用二正丙基或二正丁基亚硝胺后，除了7-丙基或7-丁基鸟嘌呤外，同时形成7-甲基鸟嘌呤]

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1971;76(2):145-54. doi: 10.1007/BF00284425.

Metabolism of nitrosamines in vivo. II. On the methylation of nucleic acids by aliphatic di-n-alkyl-nitrosamines in vivo, caused by beta-oxydation: the increased formation of 7-methyl-guanine after application of beta-hydroxypropyl-propyl-nitrosamine compared to that after application of di-n-propyl-nitrosamine.亚硝胺的体内代谢。II. 关于体内脂肪族二正烷基亚硝胺通过β-氧化作用导致核酸甲基化的研究：与应用二正丙基亚硝胺后相比，应用β-羟丙基-丙基亚硝胺后7-甲基鸟嘌呤的生成增加。

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(2):90-7. doi: 10.1007/BF00284383.

Metabolism of nitrosamines in vivo. 3. On the methylation of nucleic acids by aliphatic Di-n-alkyl-nitrosamines in vivo resueting from heta-oxidation: the formation of 7-methylguanine after application of 2-oxo-propyl-propyl-nitrosamine and methyl-propyl-nitro-samine.亚硝胺的体内代谢。3. 关于体内由β-氧化产生的脂肪族二正烷基亚硝胺对核酸的甲基化作用：应用2-氧代丙基丙基亚硝胺和甲基丙基亚硝胺后7-甲基鸟嘌呤的形成。

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973 Dec 6;80(3):189-96. doi: 10.1007/BF00284318.

Oxidative biotransformation of di-n-butylnitrosamine. Formation in vitro of aldehydes in the presence of rat liver microsomes.二正丁基亚硝胺的氧化生物转化。在大鼠肝微粒体存在的情况下醛类在体外的形成。

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):311-4. doi: 10.1007/BF00305368.

Metabolism of nitrosamines in vivo. V Investigation on 14CO2 exhalation, liver RNA labelling and isolation of two metabolites from urine after administration of [2, 5-14C-]dinitrosopiperazine to rats.

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Feb 25;85(2):125-34. doi: 10.1007/BF00304945.

Alkylation of nucleic acids by N-nitrosodi-n-propyl-amine: evidence that carbonium ions are not significantly involved.

Chem Biol Interact. 1980 Feb;29(2):139-44. doi: 10.1016/0009-2797(80)90028-9.

High mutagenicity of N-(alpha-acyloxy)alkyl-N-alkylnitrosamines in S. typhimurium: model compounds for metabolically activated N,N-dialkylnitrosamines.N-（α-酰氧基）烷基-N-烷基亚硝胺在鼠伤寒沙门氏菌中的高诱变性：代谢活化的N，N-二烷基亚硝胺的模型化合物

Mutat Res. 1978 Feb;49(2):187-94. doi: 10.1016/0027-5107(78)90156-2.

Reactive intermediates from nitrosamines.亚硝胺产生的反应中间体。

Adv Exp Med Biol. 1981;136 Pt B:1027-35.

Mutagenicity of beta-oxidized N,N,-di-n-propylnitrosamine derivatives in S. typhimurium mediated by rat and hamster tissues.大鼠和仓鼠组织介导的β-氧化N,N-二正丙基亚硝胺衍生物在鼠伤寒沙门氏菌中的致突变性

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Aug 30;86(3):293-302. doi: 10.1007/BF00286948.

[Rat urinary metabolites of (2-hydroxybutyl)-n-butylnitrosamine].（2-羟基丁基）-正丁基亚硝胺的大鼠尿液代谢产物

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975;83(2):125-7. doi: 10.1007/BF00282979.

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Carcinogenicity of vinylethylnitrosamine in Syrian golden hamsters.乙烯基乙基亚硝胺对叙利亚金仓鼠的致癌性。

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Induction of pancreas tumours by di-isopropanolnitrosamine.二异丙基亚硝胺诱导胰腺肿瘤

Naturwissenschaften. 1974 Jul;61(7):328. doi: 10.1007/BF00599567.

The carcinogenic effect of 2-oxo-propyl-propylnitrosamine in Sprague-Dawley rats.2-氧代丙基丙基亚硝胺对斯普拉格-道利大鼠的致癌作用。

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974 Mar 14;81(1):23-8. doi: 10.1007/BF00303597.

Carcinogenicity of -hydroxylated dipropylnitrosamine.γ-羟基二丙基亚硝胺的致癌性。

Naturwissenschaften. 1973 Jan;60(1):55. doi: 10.1007/BF00591776.

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(2):90-7. doi: 10.1007/BF00284383.

[Structure of rat urinary metabolites of carcinogenic dialkylnitrosamines (author's transl)].[致癌二烷基亚硝胺的大鼠尿液代谢物结构（作者译）]

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(1):3-5. doi: 10.1007/BF00284333.

[Biotransformation of carcinogenic dialkylnitrosamines. Further urinary metabolites of di-n-butyl- and di-n-pentyl-nitrosamine (author's transl)].[致癌二烷基亚硝胺的生物转化。二正丁基和二正戊基亚硝胺的进一步尿代谢产物（作者译）]

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974 Mar 14;81(1):75-8. doi: 10.1007/BF00303603.

本文引用的文献

The decomposition and toxicity of dialkylnitrosamines in rats.大鼠中二烷基亚硝胺的分解与毒性

Biochem J. 1962 Oct;85(1):72-91. doi: 10.1042/bj0850072.

Toxic liver injury and carcinogenesis. Methylation of proteins of rat-liver slices by dimethylnitrosamine in vitro.中毒性肝损伤与致癌作用。二甲基亚硝胺在体外对大鼠肝切片蛋白质的甲基化作用。

Biochem J. 1962 Apr;83(1):106-14. doi: 10.1042/bj0830106.

Toxic liver injury and carcinogenesis. Methylation of rat-liver nucleic acids by dimethylnitrosamine in vivo.毒性肝损伤与致癌作用。二甲基亚硝胺在体内对大鼠肝脏核酸的甲基化作用。

Biochem J. 1962 Apr;83(1):114-24. doi: 10.1042/bj0830114.

ISOLATION CHARACTERISTICS OF RAPIDLY LABELLED RNA FROM NORMAL RAT LIVER.正常大鼠肝脏快速标记RNA的分离特性

J Mol Biol. 1963 Sep;7:312-5. doi: 10.1016/s0022-2836(63)80010-8.

Demethylation of dimethylnitrosamine in rats and mice.大鼠和小鼠体内二甲基亚硝胺的去甲基化作用

Nature. 1956 Sep 22;178(4534):644. doi: 10.1038/178644a0.

Alkylation of rat liver RNA by cyclic N-nitrosamines in vivo.体内环状N-亚硝胺对大鼠肝脏RNA的烷基化作用。

J Natl Cancer Inst. 1966 Oct;37(4):401-7.

Cellular injury and carcinogenesis. Alkylation of ribonucleic acid of rat liver by diethylnitrosamine and n-butylmethylnitrosamine in vivo.细胞损伤与致癌作用。二乙基亚硝胺和正丁基甲基亚硝胺在体内对大鼠肝脏核糖核酸的烷基化作用。

Biochem J. 1964 Apr;91(1):35-42. doi: 10.1042/bj0910035.

Alkylation of rat liver nucleic acids not related to carcinogenesis by N-nitrosamines.

J Natl Cancer Inst. 1969 Jun;42(6):1095-100.

Nitrosamine-induced carcinogenesis. The alklylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate.亚硝胺诱导的致癌作用。N-甲基-N-亚硝基脲、二甲基亚硝胺、硫酸二甲酯和甲磺酸甲酯对大鼠核酸的烷基化作用。

Biochem J. 1968 Nov;110(1):39-47. doi: 10.1042/bj1100039.

[Studies on the alkylating effect of 14C-methylnitrosourea and 1-14C-ethylnitrosurea].

Experientia. 1968 Jun 15;24(6):592-3. doi: 10.1007/BF02153793.

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