La Vail M M
Invest Ophthalmol. 1976 Jan;15(1):64-70.
Fischer albino rats, seven weeks of age, were exposed to continuous light at 65 foot-candle incident illuminance for up to 264 days. Other Fischer rats, seven months of age, were exposed to continuous light at 140 foot-candle incident illuminance for up to 147 days. In all cases, a small percentage of the photoreceptors survived. The identification of the surviving cells as photoreceptors was made by light microscopy on the basis of nuclear heterochromatin pattern and staining and by electron microscopy by the presence of ribbon synapses and ciliary basal bodies with ciliary filaments. No outer segment membranes were observed. The percentage of cones progressively increased from the normal 1.5 per cent to about 60 per cent with increasing exposure time, indicating that cone cells are more resistant than rods to destruction by constant light.
7周龄的费希尔白化大鼠暴露于65英尺烛光入射照度的持续光照下长达264天。其他7月龄的费希尔大鼠暴露于140英尺烛光入射照度的持续光照下长达147天。在所有情况下，都有一小部分光感受器存活下来。通过光学显微镜根据核异染色质模式和染色情况，以及通过电子显微镜观察是否存在带状突触和带有纤毛丝的睫状基体，将存活细胞鉴定为光感受器。未观察到外段膜。随着暴露时间的增加，视锥细胞的百分比从正常的1.5%逐渐增加到约60%，这表明视锥细胞比视杆细胞对持续光照破坏的抵抗力更强。
