Castaneda Carmen, Layne Jennifer E, Munoz-Orians Leda, Gordon Patricia L, Walsmith Joseph, Foldvari Mona, Roubenoff Ronenn, Tucker Katherine L, Nelson Miriam E
Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA.
Diabetes Care. 2002 Dec;25(12):2335-41. doi: 10.2337/diacare.25.12.2335.
To determine the efficacy of high-intensity progressive resistance training (PRT) on glycemic control in older adults with type 2 diabetes.
We performed a 16-week randomized controlled trial in 62 Latino older adults (40 women and 22 men; mean +/- SE age 66 +/- 8 years) with type 2 diabetes randomly assigned to supervised PRT or a control group. Glycemic control, metabolic syndrome abnormalities, body composition, and muscle glycogen stores were determined before and after the intervention.
Sixteen weeks of PRT (three times per week) resulted in reduced plasma glycosylated hemoglobin levels (from 8.7 +/- 0.3 to 7.6 +/- 0.2%), increased muscle glycogen stores (from 60.3 +/- 3.9 to 79.1 +/- 5.0 mmol glucose/kg muscle), and reduced the dose of prescribed diabetes medication in 72% of exercisers compared with the control group, P = 0.004-0.05. Control subjects showed no change in glycosylated hemoglobin, a reduction in muscle glycogen (from 61.4 +/- 7.7 to 47.2 +/- 6.7 mmol glucose/kg muscle), and a 42% increase in diabetes medications. PRT subjects versus control subjects also increased lean mass (+1.2 +/- 0.2 vs. -0.1 +/- 0.1 kg), reduced systolic blood pressure (-9.7 +/- 1.6 vs. +7.7 +/- 1.9 mmHg), and decreased trunk fat mass (-0.7 +/- 0.1 vs. +0.8 +/- 0.1 kg; P = 0.01-0.05).
PRT as an adjunct to standard of care is feasible and effective in improving glycemic control and some of the abnormalities associated with the metabolic syndrome among high-risk older adults with type 2 diabetes.
确定高强度渐进性抗阻训练（PRT）对老年2型糖尿病患者血糖控制的疗效。
我们对62名患有2型糖尿病的拉丁裔老年人（40名女性和22名男性；平均±标准差年龄66±8岁）进行了一项为期16周的随机对照试验，这些患者被随机分配至接受监督的PRT组或对照组。在干预前后测定血糖控制情况、代谢综合征异常指标、身体成分和肌肉糖原储备。
16周的PRT（每周3次）导致血浆糖化血红蛋白水平降低（从8.7±0.3%降至7.6±0.2%），肌肉糖原储备增加（从60.3±3.9 mmol葡萄糖/千克肌肉增至79.1±5.0 mmol葡萄糖/千克肌肉），与对照组相比，72%的运动者所需的糖尿病药物剂量减少，P = 0.004 - 0.05。对照组受试者的糖化血红蛋白无变化，肌肉糖原减少（从61.4±7.7 mmol葡萄糖/千克肌肉降至47.2±6.7 mmol葡萄糖/千克肌肉），糖尿病药物用量增加42%。与对照组受试者相比，PRT组受试者的瘦体重也有所增加（分别为+1.2±0.2千克和 -0.1±0.1千克），收缩压降低（分别为-9.7±1.6 mmHg和+7.7±1.9 mmHg），躯干脂肪量减少（分别为-0.7±0.1千克和+0.8±0.1千克；P = 0.01 - 0.05）。
对于高危老年2型糖尿病患者，PRT作为标准治疗的辅助手段，在改善血糖控制以及一些与代谢综合征相关的异常情况方面是可行且有效的。
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