解脂耶氏酵母赖氨酸分解代谢缺陷型突变体。
Mutants of Saccharomycopsis lipolytica defective in lysine catabolism.
作者信息
Gaillardin C, Fournier P, Sylvestre G, Heslot H
出版信息
J Bacteriol. 1976 Jan;125(1):48-57. doi: 10.1128/jb.125.1.48-57.1976.
Abstract
Wild-type strains of Saccharomycopsis lipolytica are able to use lysine as a carbon or a nitrogen source, but not as a unique source for both. Mutants were selected that could not use lysine either as a nitrogen or as a carbon source. Some of them, however, utilized N-6-acetyllysine or 5-aminovaleric acid. Many of the mutants appeared to be blocked in both utilizations, suggesting a unique pathway for lysine degradation (either as a carbon or as a nitrogen source). Genetic characterization of these mutants was achieved by complementation and recombination tests.
摘要
解脂耶氏酵母的野生型菌株能够将赖氨酸用作碳源或氮源，但不能将其同时用作唯一的碳源和氮源。筛选出了既不能将赖氨酸用作氮源也不能用作碳源的突变体。然而，其中一些突变体能够利用N-6-乙酰赖氨酸或5-氨基戊酸。许多突变体在这两种利用途径上似乎都存在阻断，这表明赖氨酸降解存在一条独特的途径（无论是作为碳源还是氮源）。通过互补和重组试验对这些突变体进行了遗传特征分析。
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