L-赖氨酸-α-酮戊二酸转氨酶在谷氨酸红酵母利用赖氨酸作为氮源的分解代谢中的作用。
Role of L-lysine-alpha-ketoglutarate aminotransferase in catabolism of lysine as a nitrogen source for Rhodotorula glutinis.
作者信息
Kinzel J J, Winston M K, Bhattacharjee J K
出版信息
J Bacteriol. 1983 Jul;155(1):417-9. doi: 10.1128/jb.155.1.417-419.1983.
Abstract
Wild-type and saccharopine dehydrogenaseless mutant strains of Rhodotorula glutinis grew in minimal medium containing lysine as the sole nitrogen source and simultaneously accumulated, in the culture supernatant, large amounts of a product identified as alpha-aminoadipic-delta-semialdehyde. The saccharopine dehydrogenase and pipecolic acid oxidase levels remained unchanged in wild-type cells grown in the presence of ammonium or lysine as the nitrogen source. Lysine-alpha-ketoglutarate aminotransferase activity was demonstrated in ammonium-grown cells. This activity was depressed in cells grown in the presence of lysine as the sole source of nitrogen.
摘要
粘红酵母的野生型和无酵母氨酸脱氢酶突变株在以赖氨酸作为唯一氮源的基本培养基中生长，同时在培养上清液中积累了大量被鉴定为α-氨基己二酸-δ-半醛的产物。在以铵或赖氨酸作为氮源生长的野生型细胞中，酵母氨酸脱氢酶和哌啶酸氧化酶水平保持不变。在以铵生长的细胞中证实了赖氨酸-α-酮戊二酸转氨酶活性。在以赖氨酸作为唯一氮源生长的细胞中，该活性受到抑制。
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本文引用的文献
1
Enzymic reduction of alpha-amino-adipic acid by yeast enzyme.酵母酶对α-氨基己二酸的酶促还原作用。
Nature. 1959 Nov 28;184 (Suppl 22):1709-10. doi: 10.1038/1841709b0.
2
The conversion of lysine to pipecolic acid in the rat.大鼠体内赖氨酸向哌啶酸的转化。
J Biol Chem. 1954 Dec;211(2):851-8.
3
The metabolism of lysine in Neurospora.粗糙脉孢菌中赖氨酸的代谢
J Biol Chem. 1954 Dec;211(2):517-29.
4
Lysine biosynthesis in Rhodotorula glutinis: properties of pipecolic acid oxidase.粘红酵母中赖氨酸的生物合成：哌啶酸氧化酶的特性
J Bacteriol. 1982 Sep;151(3):1073-7. doi: 10.1128/jb.151.3.1073-1077.1982.
5
Occurrence of L-lysine epsilon-dehydrogenase in Agrobacterium tumefaciens.根癌土壤杆菌中L-赖氨酸ε-脱氢酶的存在
J Bacteriol. 1982 Apr;150(1):398-401. doi: 10.1128/jb.150.1.398-401.1982.
6
Growth inhibition by alpha-aminoadipate and reversal of the effect by specific amino acid supplements in Saccharomyces cerevisiae.α-氨基己二酸对酿酒酵母的生长抑制作用以及特定氨基酸补充剂对该作用的逆转
J Bacteriol. 1982 Nov;152(2):874-9. doi: 10.1128/jb.152.2.874-879.1982.
7
Intermediates of lysine dissimilation in the yeast, Hansenula saturnus.
Arch Biochem Biophys. 1965 Aug;111(2):467-76. doi: 10.1016/0003-9861(65)90210-9.
8
Saccharopine, a product of lysine breakdown by mammalian liver.酵母氨酸，一种哺乳动物肝脏中赖氨酸分解的产物。
Biochem Biophys Res Commun. 1965 Jul 26;20(3):285-90. doi: 10.1016/0006-291x(65)90361-x.
9
10
L-Lysine:alpha-ketoglutarate aminotransferase. I. Identification of a product, delta-1-piperideine-6-carboxylic acid.L-赖氨酸：α-酮戊二酸转氨酶。I. 一种产物δ-1-哌啶-6-羧酸的鉴定。
Biochemistry. 1968 Nov;7(11):4102-9. doi: 10.1021/bi00851a045.
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