Velnar Tomaz, Gradisnik Lidija
Department of Neurosurgery, University Medical Centre Ljubljana, Ljubljana, Slovenia.
AMEU-ECM Maribor, Slovenia.
Med Arch. 2018 Dec;72(6):444-448. doi: 10.5455/medarh.2018.72.444-448.
Wounds and their complications present a frequent cause of morbidity and mortality in everyday clinical practice. In order to reduce the wound burden, much effort has been directed into the physiology of healing and new therapeutic approaches.
This paper provides an overview from the literature about the role of endothelial and epithelial cells in tissue filler employment for wound healing.
The scientific literature was reviewed through PubMed, Medline and Science Direct. The articles were chosen in correlation with the study objective and their scientific relevance.
Successful wound healing depends on many diverse processes, cell types and molecular mediators. The definitive aim of wound healing is a properly healed wound. Tissue fillers are becoming an important alternative in wound management, although augmentation of soft tissue can present a demanding problem due to the difficulties in tissue survival. In order to prevent its failure, an optimal vascular network needs to form from wound edges into the filler.
Because of the importance of chemotaxis and angiogenesis in various physiological and pathological processes, both events present an extensive area of intense research. Additionally, epithelial cells are needed to cover the wound defect and sealing the wound environment from outer world.
在日常临床实践中，伤口及其并发症是导致发病和死亡的常见原因。为了减轻伤口负担，人们在愈合生理学和新治疗方法方面付出了很多努力。
本文对文献中内皮细胞和上皮细胞在伤口愈合组织填充应用中的作用进行综述。
通过PubMed、Medline和Science Direct检索科学文献。根据研究目的及其科学相关性选择文章。
成功的伤口愈合取决于许多不同的过程、细胞类型和分子介质。伤口愈合的最终目标是伤口得到妥善愈合。组织填充剂正成为伤口处理的重要替代方法，尽管由于组织存活困难，软组织填充可能是一个棘手的问题。为防止其失败，需要从伤口边缘到填充剂形成最佳的血管网络。
由于趋化作用和血管生成在各种生理和病理过程中的重要性，这两个过程都是广泛深入研究的领域。此外，需要上皮细胞覆盖伤口缺损并将伤口环境与外界隔离开来。
