RNA化学的发展：个人观点

Developments in RNA chemistry, a personal view.

作者信息

Eckstein F

机构信息

Max-Planck-Institut für experimentelle Medizin, Hermann-Rein-Str. 3, 37075 Göttingen, Germany.

出版信息

Biochimie. 2002 Sep;84(9):841-8. doi: 10.1016/s0300-9084(02)01459-1.

DOI:10.1016/s0300-9084(02)01459-1

PMID:12458076

Abstract

This review describes some of the contributions of chemistry to the RNA field with a personal bias towards the phosphorothioate modification and the derivatives at the ribose 2'-position. The usefulness of these modifications is discussed and documented with some examples.

摘要

本综述描述了化学对RNA领域的一些贡献，个人偏向于硫代磷酸酯修饰以及核糖2'-位的衍生物。文中讨论了这些修饰的实用性，并通过一些实例加以证明。