Departament de Química Analítica, Universitat de València, Dr. Moliner, 50, 46100 Burjassot, València, Spain.
J Pharm Biomed Anal. 2013 Jun;80:159-63. doi: 10.1016/j.jpba.2013.03.005. Epub 2013 Mar 20.
A standard additions-dilution solid-state electrochemical method for the determination of psychoactive 1,4-benzodiazepine and antidepressants drugs used as adulterants in commercial slimming herbal formulations is described and compared with conventional standard addition method. The proposed method, based on the voltammetry of microparticles approach, permits quantify, via standard additions methodology, 1,4-benzodiazepine and antidepressants drugs in phytotherapeutic formulations with no need of sample dissolution using dilution with a reference electroactive compound. The method was used to measure 1,4-benzobenzodiazepines (clonazepam, flurazepam, alprazolam, midazolam, bromazepam, chlordiazepoxide, lorazepam and diazepam) and antidepressants (bupropion, sertraline, paroxetine and fluoxetine) in slimming formulations that have been commercialized in Brazil.
一种标准加入-稀释固态电化学方法用于测定作为商业减肥草药配方中掺杂物的具有致幻作用的 1,4-苯并二氮杂䓬和抗抑郁药，该方法已被描述并与传统的标准加入方法进行了比较。该方法基于微粒电化学方法，通过标准加入方法，无需使用参考电活性化合物溶解样品，即可对植物治疗制剂中的 1,4-苯并二氮杂䓬和抗抑郁药进行定量。该方法用于测量在巴西商业化的减肥配方中的 1,4-苯并二氮䓬（氯硝西泮、氟硝西泮、阿普唑仑、咪达唑仑、溴西泮、地西泮、劳拉西泮和安定）和抗抑郁药（安非他酮、舍曲林、帕罗西汀和氟西汀）。
