Felsburg P J
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Hum Exp Toxicol. 2002 Sep-Oct;21(9-10):487-92. doi: 10.1191/0960327102ht286oa.
Dogs play an important role in toxicology because of their importance as a large animal, pre-clinical model for evaluating potential toxicity in human drug development including the effects of investigational drugs on the immune system. The purpose of this paper is to review the development of the canine immune system during the fetal, neonatal and postnatal periods and to compare it with that of the human immune system. Unlike rodents, the development of the canine immune system shares many similarities to that of the human. In both dogs and humans, the immune system, including the mucosal immune system, is fully developed before birth although the maturity of the immune response may continue into the postnatal period.
由于狗作为大型动物的重要性，它在毒理学中发挥着重要作用，是评估人类药物开发中潜在毒性（包括研究药物对免疫系统的影响）的临床前模型。本文的目的是回顾犬免疫系统在胎儿期、新生儿期和出生后时期的发育情况，并将其与人类免疫系统进行比较。与啮齿动物不同，犬免疫系统的发育与人类有许多相似之处。在狗和人类中，包括黏膜免疫系统在内的免疫系统在出生前就已完全发育，尽管免疫反应的成熟可能会持续到出生后时期。
