Strife C F, McDonald B M, Ruley E J, McAdams A J, West C D
J Pediatr. 1976 Mar;88(3):403-13. doi: 10.1016/s0022-3476(76)80254-5.
The serum complement profiles of four patients with shunt nephritis indicated classical pathway activation of the complement system. The presence of mixed cryoglobulins was correlated with disease activity and the cryoglobulins were shown to be complement reactive. Antisera to two of the cryoglobulins recognized antigens of the infecting organism, and a specific bacterial antibody was identified in one cryoglobulin, giveing evidence that the cryoglobulins contained immune complexes. Bacterial antibody without detectable antigen was demonstrable in the sera indicating antibody excess. Renal morphology demonstrated mesangial proliferation and interposition with subendothelial and mesangial deposits. Parallels are drawn with active lupus nephritis.
4例分流性肾炎患者的血清补体谱显示补体系统经典途径激活。混合性冷球蛋白的存在与疾病活动相关，且冷球蛋白显示具有补体反应性。针对两种冷球蛋白的抗血清识别感染病原体的抗原，并且在一种冷球蛋白中鉴定出特异性细菌抗体，这证明冷球蛋白含有免疫复合物。血清中可检测到无明显抗原的细菌抗体，表明抗体过剩。肾脏形态学显示系膜增生以及内皮下和系膜沉积物的插入。文中将其与活动性狼疮性肾炎进行了对比。
