Leblanc Jean-Charles, Malmauret Laure, Delobel David, Verger Philippe
Institut National de la Recherche Agronomique, DSNHSA, 147 rue de l'Université, 75 007 Paris, France.
Regul Toxicol Pharmacol. 2002 Oct;36(2):149-54. doi: 10.1006/rtph.2002.1584.
The aim of this study was to estimate the exposure to deoxynivalenol in wheat of consumers of organic and conventional products using a probabilistic method, and to compare these levels with a toxicological reference so as to provide risk managers with scientific data to be used in the regulatory decision-making process. First, a product consumption frequency questionnaire was completed by consumers of organic products, thus providing data on the consumption of organic products. Data on the consumption of conventional products were obtained from the French "INCA" survey. Data on deoxynivalenol levels in wheat came from a previous study. The results of exposure simulations using the Monte-Carlo sampling method showed that 10% of those consuming organic wheat containing deoxynivalenol may be exposed to this natural toxin at levels above the provisional maximum tolerable daily intake.
本研究的目的是使用概率方法估计有机产品和传统产品消费者从小麦中摄入脱氧雪腐镰刀菌烯醇的情况,并将这些水平与毒理学参考值进行比较,以便为风险管理者提供用于监管决策过程的科学数据。首先,有机产品消费者填写了一份产品消费频率问卷,从而提供了有机产品消费的数据。传统产品消费的数据来自法国的“INCA”调查。小麦中脱氧雪腐镰刀菌烯醇水平的数据来自先前的一项研究。使用蒙特卡洛抽样方法进行的暴露模拟结果表明,食用含有脱氧雪腐镰刀菌烯醇的有机小麦的人群中,有10%可能会接触到超过暂定每日最大耐受摄入量水平的这种天然毒素。