Grinberg A, Markovics A, Galindez J, Lopez-Villalobos N, Kosak A, Tranquillo V M
Institute of Veterinary Animal and Biomedical Sciences, Massey University, Private Bag 11.222, Palmerston North, New Zealand.
Vet Rec. 2002 Nov 16;151(20):606-8. doi: 10.1136/vr.151.20.606.
A prospective, controlled-blind field trial was conducted to evaluate the efficacy and safety of paromomycin sulphate, given for 10 days from birth, in preventing natural cryptosporidiosis in calves. In the untreated control group, oocyst shedding and diarrhoea followed the pattern that had occurred on the farm before the trial, consistent with a perinatal infection, whereas in the treated group, the prepatent period was significantly longer than in the control group (P < 0.01) and oocyst shedding and diarrhoea started only after the drug was withdrawn. However, the regimen did not reduce the incidence of disease in the treated group.
进行了一项前瞻性、对照盲法田间试验，以评估从出生起给予10天硫酸巴龙霉素预防犊牛自然隐孢子虫病的疗效和安全性。在未治疗的对照组中，卵囊排出和腹泻遵循试验前农场出现的模式，与围产期感染一致，而在治疗组中，潜伏期明显长于对照组（P<0.01），卵囊排出和腹泻仅在停药后开始。然而，该方案并未降低治疗组的疾病发病率。
