Moretti Rita, Torre Paola, Antonello Rodolpho M, Cazzato Giuseppe, Bava Antonio
Dipartimento di Fisiologia e Patologia, UCO di Neurologia, Università di Trieste, Italia.
Eur Neurol. 2003;49(1):13-9. doi: 10.1159/000067021.
Frontotemporal dementia (FTD) represents an important cause for degenerative disruption and is increasingly recognized as an important cause (up to 25%) of degenerative dementia among late-middle-age individuals. The serotoninergic system is tightly bound to frontal circuits, whose degeneration subserves FTD. Patients aged 64-68 years, with a diagnosis of FTD, were randomized to receive paroxetine up to 20 mg/day (n = 8) or piracetam up to 1,200 mg/day (n = 8). At 14 months, the patients treated with paroxetine showed significant improvements in behavioral symptoms, reflected by a reduction of caregiver stress. Side effects were easily tolerable, and there was no dropout. The results are presented with an overview of the literature on the topic.
额颞叶痴呆（FTD）是退行性神经功能紊乱的一个重要病因，并且越来越被认为是中老年个体中退行性痴呆的一个重要病因（高达25%）。血清素能系统与额叶回路紧密相连，额叶回路的退化是FTD的发病基础。64至68岁被诊断为FTD的患者被随机分为两组，一组接受每日剂量高达20毫克的帕罗西汀治疗（n = 8），另一组接受每日剂量高达1200毫克的吡拉西坦治疗（n = 8）。在14个月时，接受帕罗西汀治疗的患者行为症状有显著改善，表现为照顾者压力减轻。副作用易于耐受，且无患者退出研究。本文呈现了该主题的文献综述及研究结果。
