Lin Elaine Y, Gouon-Evans Valerie, Nguyen Andrew V, Pollard Jeffrey W
Center for Study of Reproductive Biology and Women's Health, Departments of Developmental and Molecular Biology and Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, New York, New York 10461, USA.
J Mammary Gland Biol Neoplasia. 2002 Apr;7(2):147-62. doi: 10.1023/a:1020399802795.
Colony stimulating factor 1 (CSF-1), a major regulator of the mononuclear phagocytic lineage, is expressed in more than 70% of human breast cancers and its expression is correlated with poor prognosis. Studies of CSF-1 null mutant mice demonstrated that CSF-1 plays an important role in normal mammary ductal development as well as in mammary tumor progression to metastasis. CSF-1 regulates these processes through the recruitment and regulation of macrophages, cells that become associated with mammary tumors and the terminal end buds at the end of the growing ducts. This phenomenon suggests that the tumors subvert normal developmental processes to allow invasion into the surrounding stroma, a process that gives the tumor access to the vasculature and consequently the promotion of metastasis. In addition, soluble CSF-1 secreted from the tumor acts to divert antitumor macrophage responses and suppresses the differentiation of mature tumor-antigen-presenting dendritic cell This review discusses these observations in detail and attempts to fit them into a larger picture of CSF-1 and macrophage action in the regulation of normal mammary gland development and tumor progression.
集落刺激因子1（CSF-1）是单核吞噬细胞系的主要调节因子，在70%以上的人类乳腺癌中表达，其表达与预后不良相关。对CSF-1基因敲除突变小鼠的研究表明，CSF-1在正常乳腺导管发育以及乳腺肿瘤进展至转移过程中发挥重要作用。CSF-1通过招募和调节巨噬细胞来调控这些过程，巨噬细胞是与乳腺肿瘤以及生长导管末端的终末芽相关的细胞。这种现象表明肿瘤颠覆了正常的发育过程，从而得以侵入周围的基质，这一过程使肿瘤能够接触血管，进而促进转移。此外，肿瘤分泌的可溶性CSF-1可改变抗肿瘤巨噬细胞反应，并抑制成熟的肿瘤抗原呈递树突状细胞的分化。本综述详细讨论了这些观察结果，并试图将它们纳入CSF-1和巨噬细胞在正常乳腺发育和肿瘤进展调节中的整体作用框架。
