Fujimori S, Kishida T, Mitsui K, Yonezawa M, Nagata K, Shibata Y, Tanaka S, Tatsuguchi A, Sato J, Yokoi K, Tanaka N, Ohaki Y, Sakamoto C, Kobayashi M
Third Dept. of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Scand J Gastroenterol. 2002 Nov;37(11):1309-12. doi: 10.1080/003655202761020597.
There have been no reports that low serum cholesterol levels increase the risk of colorectal adenoma, although many studies have shown that they do increase the risk of colorectal cancer. Alcohol intake, which is associated with a risk of colorectal adenomas, and serum cholesterol levels are closely related. The purpose of this study was to evaluate the influence of alcohol consumption on the association between serum cholesterol levels and colorectal adenoma.
The subjects were 1,349 male patients who underwent both barium enema examination and total colonoscopy. They answered a questionnaire regarding their alcohol consumption history, and their blood samples were analysed. The subjects were divided into three groups: those with no tumour (with neither adenoma nor adenocarcinoma), those with adenoma and those with adenocarcinoma. Among the groups, the serum total cholesterol and triglyceride levels were compared in all the patients, in the patients who did not drink daily and in the patients who did.
In all the patients, the serum cholesterol and triglyceride levels did not differ between the patients with and those without adenoma. In the daily drinkers, the serum cholesterol and triglyceride levels were significantly lower in patients with adenoma than in those without.
Significantly lower levels of serum cholesterol and triglycerides were found in daily drinkers with adenoma than in those without.
尽管许多研究表明低血清胆固醇水平会增加患结直肠癌的风险，但尚无报告表明其会增加患大肠腺瘤的风险。与大肠腺瘤风险相关的酒精摄入量与血清胆固醇水平密切相关。本研究的目的是评估饮酒对血清胆固醇水平与大肠腺瘤之间关联的影响。
研究对象为1349名接受了钡灌肠检查和全结肠镜检查的男性患者。他们回答了一份关于饮酒史的问卷，并对其血液样本进行了分析。研究对象被分为三组：无肿瘤组（既无腺瘤也无腺癌）、腺瘤组和腺癌组。在这些组中，比较了所有患者、不每日饮酒的患者和每日饮酒的患者的血清总胆固醇和甘油三酯水平。
在所有患者中，有腺瘤和无腺瘤患者的血清胆固醇和甘油三酯水平没有差异。在每日饮酒者中，腺瘤患者的血清胆固醇和甘油三酯水平显著低于无腺瘤患者。
发现每日饮酒且患有腺瘤的患者的血清胆固醇和甘油三酯水平显著低于未患腺瘤的患者。
