Li Chuan-feng, Li Jun, Bai Peng, Lv Yu-min
Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Jun 18;43(3):432-5.
To evaluate the relationship between serum lipid level and colorectal adenoma.
A review analysis was carried out of the patients who underwent colonoscopy in Peking University Third Hospital from May 2009 to February 2010. Subjects with history of colorectal adenocarcinoma before colorectal surgery or of medication which had influenced the serum lipid level were excluded. Adenoma group included the patients who had colorectal adenoma which was evidenced by pathology. The patients with no adenoma were ascribed to control group. The serum total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol levels of the two groups were analyzed. The relation between serum lipid level and location of colorectal adenoma was also summarized.
A total of 227 patients were included for final analysis, of whom 124 were in adenoma group (77 males and 47 females; mean age: 56.5±10.7 years )and 103 in control group(53 males and 50 females; mean age: 56.8±13.6 years). Serum triglyceride level in adenoma group [(1.83±1.04) mmol/L] was significantly higher than that of control group[(1.54±0.86) mmol/L(P=0.022)] and HDL-C level in adenoma group[(1.05±0.32) mmol / L] was significantly lower than that of control group [(1.26±0.46) mmol/L(P=0.000)]. In adenoma group, 73 cases were with HDL-C decreased, which was significantly higher than that of control group (44 cases, P=0.015). In addition, higher incidence of proximal colonic adenomas was observed in elevated triglycerides group and low HDL-C group (39.8%, 37.4%), compared with control group (25.5%), but there was no statistical difference between the two groups(P=0.358).
The findings of this study suggest that dyslipidemia may affect the incidence of colorectal adenoma, particularly hypertriglyceridemia and low HDL-C levels. In addition, higher triglyceride and lower HDL-C levels seem to be related to higher incidence of proximal colonic adenomas.
评估血清脂质水平与结直肠腺瘤之间的关系。
对2009年5月至2010年2月在北京大学第三医院接受结肠镜检查的患者进行回顾性分析。排除结直肠手术前有结直肠癌病史或使用过影响血清脂质水平药物的受试者。腺瘤组包括经病理证实患有结直肠腺瘤的患者。无腺瘤的患者归入对照组。分析两组患者的血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平。还总结了血清脂质水平与结直肠腺瘤位置之间的关系。
共纳入227例患者进行最终分析，其中腺瘤组124例（男性77例，女性47例；平均年龄：56.5±10.7岁），对照组103例（男性53例，女性50例；平均年龄：56.8±13.6岁）。腺瘤组血清甘油三酯水平[（1.83±1.04）mmol/L]显著高于对照组[（1.54±0.86）mmol/L，P = 0.022]，腺瘤组高密度脂蛋白胆固醇水平[（1.05±0.32）mmol/L]显著低于对照组[（1.26±0.46）mmol/L），P = 0.000]。腺瘤组中73例高密度脂蛋白胆固醇降低，显著高于对照组（44例，P = 0.015）。此外，甘油三酯升高组和高密度脂蛋白胆固醇降低组近端结肠腺瘤的发生率较高（分别为39.8%、37.4%），高于对照组（25.5%），但两组之间无统计学差异（P = 0.358）。
本研究结果表明血脂异常可能影响结直肠腺瘤的发生率，尤其是高甘油三酯血症和低高密度脂蛋白胆固醇水平。此外，较高的甘油三酯水平和较低的高密度脂蛋白胆固醇水平似乎与近端结肠腺瘤的较高发生率有关。
