Kono S, Ikeda N, Yanai F, Yamamoto M, Shigematsu T
Department of Public Health, Fukuoka University School of Medicine, Japan.
Int J Epidemiol. 1990 Jun;19(2):274-8. doi: 10.1093/ije/19.2.274.
Colorectal adenoma is regarded as a precursor lesion of adenocarcinoma. In view of the controversy on serum cholesterol and colorectal cancer, the risk of colorectal adenoma was examined in relation to serum total cholesterol, triglycerides and HDL-cholesterol. In the comparison of 88 men having adenoma and 1055 men with normal colonoscopy, there was no association between serum total cholesterol and colorectal adenoma. An increased risk of adenoma was observed at the highest quartile of triglycerides and at the lowest of HDL-cholesterol. When the three serum lipids were simultaneously examined, only the relation with HDL-cholesterol remained unchanged giving odds ratio of 1.7 at the lowest quartile compared with the upper three combined (p less than 0.05). The present study is consistent with the view that the inverse relation between serum total cholesterol and colorectal cancer is due to the effects of preclinical cancer. Further clarification is needed on low HDL-cholesterol and colorectal adenoma.
大肠腺瘤被视为腺癌的前驱病变。鉴于血清胆固醇与结直肠癌之间存在争议，研究了血清总胆固醇、甘油三酯和高密度脂蛋白胆固醇与大肠腺瘤风险的关系。在比较88例患有腺瘤的男性和1055例结肠镜检查正常的男性时，血清总胆固醇与大肠腺瘤之间没有关联。在甘油三酯最高四分位数和高密度脂蛋白胆固醇最低四分位数时，观察到腺瘤风险增加。当同时检测三种血脂时，只有与高密度脂蛋白胆固醇的关系保持不变，最低四分位数与上三个四分位数合并相比的优势比为1.7（p小于0.05）。本研究与以下观点一致，即血清总胆固醇与结直肠癌之间的负相关是由于临床前癌症的影响。关于低高密度脂蛋白胆固醇与大肠腺瘤，还需要进一步阐明。
