UCS1025A和B，来自枝顶孢属真菌的新型抗肿瘤抗生素。

UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species.

作者信息

Agatsuma Tsutomu, Akama Tsutomu, Nara Shinji, Matsumiya Shigeki, Nakai Ryuichiro, Ogawa Harumi, Otaki Shizuo, Ikeda Shun-Ichi, Saitoh Yutaka, Kanda Yutaka

机构信息

Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3-6-6 Asahimachi, Machida, Japan.

出版信息

Org Lett. 2002 Dec 12;4(25):4387-90. doi: 10.1021/ol026923b.

DOI:10.1021/ol026923b

PMID:12465894

Abstract

[structure: see text] UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, were isolated from the fungus Acremonium sp. KY4917. The structures and stereochemistry were elucidated by a combination of two-dimensional NMR and X-ray crystallographic analysis. UCS1025A showed unique chemical equilibria involving three tautomeric isomers and exhibited antimicrobial activity and antiproliferative activity against human tumor cell lines.

摘要

[结构：见正文] UCS1025A和B是从真菌枝顶孢属菌株KY4917中分离得到的具有前所未有的呋喃吡咯里西啶骨架的新型五环聚酮化合物。通过二维核磁共振和X射线晶体学分析相结合的方法阐明了其结构和立体化学。UCS1025A表现出涉及三种互变异构体的独特化学平衡，并对人类肿瘤细胞系具有抗菌活性和抗增殖活性。