来自链霉菌属的细胞毒性二氢苯并嗪 D-F。

Cytotoxic Dibohemamines D-F from a Streptomyces Species.

机构信息

Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.

出版信息

J Nat Prod. 2017 Oct 27;80(10):2825-2829. doi: 10.1021/acs.jnatprod.7b00136. Epub 2017 Oct 16.

DOI:10.1021/acs.jnatprod.7b00136

PMID:29035560

Abstract

Three dimeric analogues of bohemamines, dibohemamines D-F (1-3), together with dibohemamine A (4), were isolated from Streptomyces sp. CPCC 200497. Their structures were solved using a combination of mass spectrometry, 1D and 2D NMR spectroscopy, and CD. Dibohemamines D and E were new dimeric analogues of bohemamines, and dibohemamine F was a known compound obtained previously by semisynthesis. Dibohemamine F displayed potent cytotoxicity against cancer cell lines A549 and HepG2 with IC values of 1.1 and 0.3 μM, respectively. Dibohemamines D and E showed moderate cytotoxicity against cancer cell lines A549 and HepG2.

摘要

从链霉菌 sp. CPCC 200497 中分离得到了三个倍半萜生物碱二倍半萜胺 D-F（1-3）与二倍半萜胺 A（4）。通过质谱、1D 和 2D NMR 光谱以及圆二色谱联用，解析了它们的结构。二倍半萜胺 D 和 E 是倍半萜胺的新型二聚体类似物，二倍半萜胺 F 是以前通过半合成得到的已知化合物。二倍半萜胺 F 对肺癌细胞系 A549 和 HepG2 表现出较强的细胞毒性，IC 值分别为 1.1 和 0.3 μM。二倍半萜胺 D 和 E 对肺癌细胞系 A549 和 HepG2 也表现出中等的细胞毒性。