沙罗头孢菌素 A-C，硫代二酮哌嗪类化合物，来源于红树林真菌Sarocladium kiliense HDN11-84。

Saroclazines A-C, thio-diketopiperazines from mangrove-derived fungi Sarocladium kiliense HDN11-84.

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.

Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, People's Republic of China.

出版信息

Arch Pharm Res. 2018 Jan;41(1):30-34. doi: 10.1007/s12272-017-0961-7. Epub 2017 Nov 4.

DOI:10.1007/s12272-017-0961-7

PMID:29103141

Abstract

Three new diketopiperazine derivatives (DKPs), saroclazines A-C (1-3) along with three known DKPs (4-6) were isolated from mangrove-derived fungi Sarocladium kiliense HDN11-84. Saroclazines A-B (1 and 2) possessed a free amide structure, which was first found in sulfur-containing aromatic DKPs. Their structures were elucidated by NMR, HRESIMS and X-ray. The cytotoxic activity of new compounds (1-3) was tested against HeLa cell lines, among which compound 2 showed an IC value of 4.2 µM.

摘要

从红树林来源真菌Sarocladium kiliense HDN11-84 中分离得到了三种新的二酮哌嗪衍生物（DKPs），saroclazines A-C（1-3）以及三种已知的 DKPs（4-6）。Saroclazines A-B（1 和 2）具有游离的酰胺结构，这在含硫芳香族 DKPs 中是首次发现。通过 NMR、HRESIMS 和 X 射线确定了它们的结构。对新化合物（1-3）进行了抗 HeLa 细胞系的细胞毒性活性测试，其中化合物 2 的 IC 值为 4.2 µM。