通过方酸酯级联反应高效简捷地合成戊搭烯。
A highly abbreviated synthesis of pentalenene by means of the squarate ester cascade.
作者信息
Paquette Leo A, Geng Feng
机构信息
Evans Chemical Laboratories, The Ohio State University, Columbus 43210, USA.
出版信息
Org Lett. 2002 Dec 12;4(25):4547-9. doi: 10.1021/ol020208k.
PMID:12465934
Abstract
[reaction: see text] The sequential addition of 5-methylcyclopentyllithium and propynyllithium to diisopropyl squarate results in the efficient formation of a functionalized angular triquinane having two of its five-membered rings substituted precisely as in the target sesquiterpene. Only seven additional steps are then required to access pentalenene.
摘要
[反应：见正文] 依次将5-甲基环戊基锂和丙炔基锂加入到二异丙基方酸酯中，可高效形成一种官能化的角型三环癸烷，其五个环中的两个环的取代方式与目标倍半萜烯完全相同。随后只需再经过七个步骤即可得到戊塔烯。
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