Nauli Andromeda M, Zheng Shuqin, Yang Qing, Li Ronggui, Jandacek Ronald, Tso Patrick
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0529, USA.
Am J Physiol Gastrointest Liver Physiol. 2003 Apr;284(4):G583-7. doi: 10.1152/ajpgi.00482.2002. Epub 2002 Dec 4.
Intestinal alkaline phosphatase (IAP) is one of the major sources of alkaline phosphatase in circulation. It is secreted into the intestinal lumen, serum, and lymph. After the ingestion of lipid, lymphatic alkaline phosphatase secretion increases significantly. We have found that the nonabsorbable fat olestra is unable to stimulate lymphatic alkaline phosphatase secretion. We also found that the hydrophobic surfactant Pluronic L-81, which blocks chylomicron formation, fails to inhibit this increase in lymphatic alkaline phosphatase secretion. These results suggest that it is the lipid uptake into the mucosa and/or reesterification to form triacylglycerols, but not the formation of chylomicrons, that is necessary for the stimulation of the secretion of alkaline phosphatase into the lymph.
肠碱性磷酸酶（IAP）是循环中碱性磷酸酶的主要来源之一。它分泌到肠腔、血清和淋巴中。摄入脂质后，淋巴碱性磷酸酶的分泌显著增加。我们发现不可吸收的脂肪奥利司他无法刺激淋巴碱性磷酸酶的分泌。我们还发现，阻断乳糜微粒形成的疏水性表面活性剂普朗尼克L-81并不能抑制淋巴碱性磷酸酶分泌的这种增加。这些结果表明，脂质摄取到黏膜中和/或重新酯化形成三酰甘油，而不是乳糜微粒的形成，是刺激碱性磷酸酶分泌到淋巴中所必需的。
