Etra W, Surgalla M, Wajsman Z, Baumgartner G, Merrin C
Urology. 1976 Feb;7(2):160-4. doi: 10.1016/0090-4295(76)90303-4.
Twenty-one patients with gram-negative urinary tract infections were treated with sisomicin, a new aminoglycoside antibiotic. Bacteriologic cure was achieved in 62 per cent of patients, and improvement in another 33 per cent. Mild transient elevation of serum creatinine occurred in 3 patients. No other toxicity was observed. Further clinical trials with more frequent dose administration and in combination with other antibiotics is suggested.
21例革兰氏阴性菌引起的尿路感染患者接受了新的氨基糖苷类抗生素西索米星治疗。62%的患者实现了细菌学治愈，另有33%的患者病情有所改善。3例患者出现血清肌酐轻度短暂升高。未观察到其他毒性反应。建议进行更频繁给药以及与其他抗生素联合使用的进一步临床试验。
