卵巢甲状腺样类癌肿瘤：一例表现为与肽YY相关的严重便秘的病例。
Strumal carcinoid tumor of the ovary: a case exhibiting severe constipation associated with PYY.
作者信息
Matsuda Kyoko, Maehama Toshiyuki, Kanazawa Koji
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, University of the Ryukyus, 207 Uehara Nishihara-Machi, Nakagami-Gun, Okinawa, Japan.
出版信息
Gynecol Oncol. 2002 Oct;87(1):143-5. doi: 10.1006/gyno.2002.6785.
BACKGROUND
Primary carcinoid tumor of the ovary is uncommon and represents less than 0.1% of ovarian malignancy. Recently, it was reported that the strumal carcinoid tumor may be complicated by severe constipation as one symptom of the carcinoid syndrome.
CASE
A 50-year-old nulliparous woman complained of persisting constipation and abdominal distention with pelvic mass, raising the possibility of ovarian tumor. The sugically resected tumor was diagnosed as strumal carcinoid tumor. Her long-lasting severe constipation completely disappeared after tumor removal but recurred with recurrent hepatic disease. The tumor cells were positive for PYY, a peptide hormone that has a strong inhibitory effect on intestinal motility, by immunohistochemical stain.
CONCLUSION
Our case provides the more convincing information to indicate that PYY protein, produced by ovarian tumor cells in the trabecular carcinoid component, may be associated with severe constipation.
背景
原发性卵巢类癌肿瘤并不常见，占卵巢恶性肿瘤的比例不到0.1%。最近有报道称，甲状腺肿类癌肿瘤可能并发严重便秘，这是类癌综合征的一种症状。
病例
一名50岁未生育女性主诉持续便秘、腹胀并伴有盆腔肿块，提示存在卵巢肿瘤的可能性。手术切除的肿瘤被诊断为甲状腺肿类癌肿瘤。肿瘤切除后，她长期的严重便秘完全消失，但随着肝病复发而再次出现。通过免疫组织化学染色，肿瘤细胞对PYY呈阳性，PYY是一种对肠道蠕动有强烈抑制作用的肽类激素。
结论
我们的病例提供了更有说服力的信息，表明小梁状类癌成分中的卵巢肿瘤细胞产生的PYY蛋白可能与严重便秘有关。
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