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卵巢产生肽YY的甲状腺肿样类癌病例:一例报告及文献复习

Case of peptide-YY-producing strumal carcinoid of the ovary: a case report and review.

作者信息

Takatori Eriko, Shoji Tadahiro, Miura Jiyu, Takeuchi Satoshi, Yoshizaki Akira, Sugiyama Toru

机构信息

Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Iwate, Japan.

出版信息

J Obstet Gynaecol Res. 2012 Oct;38(10):1266-70. doi: 10.1111/j.1447-0756.2012.01859.x. Epub 2012 May 8.

Abstract

Ovarian carcinoid is a rare tumor accounting for approximately 0.1% of all ovarian malignancies. We describe a case of peptide-YY-producing strumal carcinoid of the ovary associated with severe constipation. A 48-year-old woman was found to have a pelvic mass on ultrasonography when she visited her primary doctor for a health check-up. She was thus referred to our department. Magnetic resonance imaging revealed a solid right ovarian tumor 60 × 50 mm in size. The patient underwent a right adnexectomy and was histopathologically diagnosed as having strumal carcinoid of the ovary. On immunohistochemical examination, the tumor cells were positive for peptide YY. The patient's constipation resolved rapidly after surgery. Based on her clinical course, her constipation was considered to have been caused by the strumal carcinoid of the ovary. The clinical course of this case supports the previously recognized correlation between peptide-YY-producing ovarian carcinoid and constipation.

摘要

卵巢类癌是一种罕见肿瘤,约占所有卵巢恶性肿瘤的0.1%。我们报告一例产生肽YY的卵巢甲状腺肿类癌伴严重便秘的病例。一名48岁女性在因健康检查就诊于她的初级医生时,超声检查发现盆腔有肿物。因此她被转诊至我们科室。磁共振成像显示右侧卵巢有一个大小为60×50mm的实性肿瘤。患者接受了右侧附件切除术,组织病理学诊断为卵巢甲状腺肿类癌。免疫组化检查显示肿瘤细胞肽YY呈阳性。患者术后便秘迅速缓解。根据其临床病程,认为她的便秘是由卵巢甲状腺肿类癌引起的。该病例的临床病程支持了先前公认的产生肽YY的卵巢类癌与便秘之间的相关性。

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