Francis James, Carty John E, Scott Brian B
Department of Rheumatology, Lincoln County Hospital, UK.
Eur J Gastroenterol Hepatol. 2002 Dec;14(12):1355-6. doi: 10.1097/00042737-200212000-00011.
To determine the prevalence of coeliac disease in rheumatoid arthritis.
One hundred and sixty patients with seropositive rheumatoid arthritis were tested for the endomysial antibody. Those found positive were studied further with endoscopic small bowel biopsy.
Only one patient was found to have coeliac disease, and that had already been diagnosed. Thus the prevalence of previously undiagnosed coeliac disease in rheumatoid arthritis is 0 (95% CI 0-0.24%) and the overall prevalence of coeliac disease is 0.63% (95% CI 0.1-3.5%). These prevalences are not significantly different from the reported prevalences of coeliac disease in the general population.
This study does not support an association between coeliac disease and seropositive rheumatoid arthritis or the screening of such patients for coeliac disease.
确定类风湿关节炎患者中乳糜泻的患病率。
对160例血清阳性类风湿关节炎患者进行肌内膜抗体检测。对检测呈阳性者进一步行内镜下小肠活检。
仅发现1例患者患有乳糜泻，且该患者已被确诊。因此，类风湿关节炎患者中既往未诊断出的乳糜泻患病率为0（95%可信区间0 - 0.24%），乳糜泻总体患病率为0.63%（95%可信区间0.1 - 3.5%）。这些患病率与普通人群中报道的乳糜泻患病率无显著差异。
本研究不支持乳糜泻与血清阳性类风湿关节炎之间存在关联，也不支持对此类患者进行乳糜泻筛查。
