Alghofaili Nouf, Ismail Samaher, Aladnani Abdullah, Alfarsi Abdullah, Aqabawi Sally, Shahat Ghofran, Zakariyah Abeer, Alhazmi Ahmed, Albeshri Tariq
Department of Medicine, King Fahad Armed Forced Hospital, Jeddah, Saudi Arabia.
Department of Medical Genetics, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia.
SAGE Open Med. 2024 Sep 25;12:20503121241283335. doi: 10.1177/20503121241283335. eCollection 2024.
Rheumatoid arthritis is a severe inflammatory arthritis that causes irreversible damage to joints and bones, resulting in deformities and disabilities. Population-based studies on the co-occurrence in patients with rheumatoid arthritis are lacking despite shared mechanisms with other autoimmune diseases.
This study aimed to determine the prevalence and association of autoimmune diseases among patients with rheumatoid arthritis and explore the associations between autoimmune diseases and treatment options for rheumatoid arthritis.
This retrospective study was conducted from 2019 to 2023 at King Fahad Armed Forces Hospitals, Jeddah, Saudi Arabia. Data were cleaned in Excel and analyzed using IBM SPSS version 29. The activity of the disease was assessed through clinical manifestations, laboratory findings, and its associations with other autoimmune diseases.
Our study included 365 patients with rheumatoid arthritis, predominantly female (89%), and observed diverse demographics and comorbidities. Prevalent conditions included diabetes mellitus (28.2%), hypertension (27.3%), and dyslipidemia (14.7%). Other autoimmune diseases were present in 24.9% of patients, with notable associations with age at rheumatoid arthritis diagnosis and endocrine, rheumatology/dermatology, and pulmonary disorders ( < 0.001). Treatment approaches varied, with prednisolone (24.4%) and methotrexate (55.1%) being predominant. No significant associations were observed between autoimmune disorders and specific treatment modalities ( > 0.05).
Our study provides a thorough overview of rheumatoid arthritis in a large cohort, revealing demographic trends, comorbidities, autoimmune disease prevalence, treatment preferences, and associations. Relationships with age at rheumatoid arthritis diagnosis and other autoimmune diseases were noted. Treatment approaches varied, with no significant associations between autoimmune disorders and specific modalities.
类风湿性关节炎是一种严重的炎症性关节炎，会对关节和骨骼造成不可逆转的损害，导致畸形和残疾。尽管与其他自身免疫性疾病有共同机制，但缺乏基于人群的类风湿性关节炎患者共病情况研究。
本研究旨在确定类风湿性关节炎患者中自身免疫性疾病的患病率及关联，并探讨自身免疫性疾病与类风湿性关节炎治疗方案之间的关联。
本回顾性研究于2019年至2023年在沙特阿拉伯吉达的法赫德国王武装部队医院进行。数据在Excel中进行清理，并使用IBM SPSS 29版进行分析。通过临床表现、实验室检查结果及其与其他自身免疫性疾病的关联来评估疾病活动度。
我们的研究纳入了365例类风湿性关节炎患者，以女性为主（89%），观察到了不同的人口统计学特征和合并症。常见疾病包括糖尿病（28.2%）、高血压（27.3%）和血脂异常（14.7%）。24.9%的患者患有其他自身免疫性疾病，与类风湿性关节炎诊断时的年龄以及内分泌、风湿/皮肤科和肺部疾病显著相关（<0.001）。治疗方法各不相同，以泼尼松龙（24.4%）和甲氨蝶呤（55.1%）为主。未观察到自身免疫性疾病与特定治疗方式之间存在显著关联（>0.05）。
我们的研究全面概述了一大群类风湿性关节炎患者的情况，揭示了人口统计学趋势、合并症、自身免疫性疾病患病率、治疗偏好及关联。注意到了与类风湿性关节炎诊断时年龄及其他自身免疫性疾病的关系。治疗方法各不相同，自身免疫性疾病与特定治疗方式之间无显著关联。
