Kawauchi Shigeto, Hayatsu Yoshikazu, Takahashi Mutsuo, Furuya Tomoko, Oga Atsunori, Niwa Shin-Ichiro, Sasaki Kohsuke
Department of Pathology, Yamaguchi University School of Medicine, Japan.
Oncol Rep. 2003 Jan-Feb;10(1):31-4.
Spindle-cell ameloblastic carcinoma is a classification proposed for a group of rare odontogenic carcinomas with sarcomatoid components and is distinguished from odontogenic carcinosarcoma. We report a case of spindle-cell ameloblastic carcinoma of the right mandible that occurred in a 67-year-old Japanese man. Growth of the tumor was destructive, there was extensive lung metastasis, and the outcome was unfavorable. Ultrastructural and immunohistochemical examination showed the spindle-cell component of the tumor to be epithelial in character. A gain of 5q with amplification of 5q13 was detected in the tumor by comparative genomic hybridization.
梭形细胞成釉细胞癌是为一组具有肉瘤样成分的罕见牙源性癌所提出的分类，它与牙源性癌肉瘤有所区别。我们报告一例发生于一名67岁日本男性的右下颌骨梭形细胞成釉细胞癌。肿瘤生长具有破坏性，存在广泛肺转移，预后不佳。超微结构和免疫组化检查显示肿瘤的梭形细胞成分具有上皮特征。通过比较基因组杂交在肿瘤中检测到5号染色体长臂（5q）获得并伴有5q13扩增。
