Department of Oral and Maxillofacial Pathology, MM College of Dental Sciences and Research, Mullana-133203, Ambala, Haryana, India.
Curr Oncol. 2010 Oct;17(5):52-7. doi: 10.3747/co.v17i5.580.
Spindle-cell differentiation in ameloblastic carcinoma is a rare event. Although reported by many authors, it was first described as a separate entity in 1999 by Slater under the heading "low-grade spindle-cell ameloblastic carcinoma." Here, we report a case of low-grade spindle-cell ameloblastic carcinoma arising in pre-existing unicystic ameloblastoma.The patient, a 60-year-old Indian woman, had a large irregular swelling in the left mandibular region. Histologically, the lesion was composed of a large cystic cavity with an ameloblastomatous lining and areas showing spindle-cell proliferation. The spindle cells showed hyperchromatism, nuclear pleomorphism, and scattered mitotic figures. To our knowledge, 6 cases of spindle-cell ameloblastic carcinoma have been published to date, and this case appears to be the first reporting malignant transformation with spindle-cell differentiation in unicystic ameloblastoma.
成釉细胞瘤中出现梭形细胞分化是一种罕见现象。虽然有许多作者对此进行了报道，但它是在 1999 年由 Slater 首次以“低度梭形细胞成釉细胞瘤”为题作为一个独立实体进行描述的。在此，我们报告了一例在已存在的单囊成釉细胞瘤中发生的低度梭形细胞成釉细胞瘤。患者为 60 岁的印度女性，左下颌区域有一较大不规则肿胀。组织学上，病变由一个大的囊腔组成，具有成釉细胞瘤样的衬里和显示梭形细胞增生的区域。梭形细胞显示深染、核异型性和散在的有丝分裂象。据我们所知，迄今为止已经发表了 6 例梭形细胞成釉细胞瘤，而本例似乎是首例报道在单囊成釉细胞瘤中出现恶性转化伴梭形细胞分化的病例。
