撒丁岛的免疫球蛋白同种异型

Immunoglobulin allotypes in Sardinia.

作者信息

Piazza A, van Loghem E, de Lange G, Curtoni E S, Ulizzi L, Terrenato L

出版信息

Am J Hum Genet. 1976 Jan;28(1):77-86.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1684902/

Abstract

1218 individuals from Sardinia island (Italy) were tested for Gm and Km markers; 10 were not tested for Gm and only 401 were typed for Am markers. The peculiar genetic makeup of the Sardinian population is confirmed by their Gm allotypes. Their differences from those found in a control population of continental Italy (Ferrara), suggest ancient contacts with the Middle East and Africa. An indication for such contacts may also be found in the striking presence of the haplotype Gm f;n;bsc5, a haplotype not previously found in a human population. A significant difference of G2m(n) allotype was observed between highland and lowland regions. If confirmed, it may suggest an adaptive pressure related to the CH2 region of the gamma2 chain, possibly due to endemic malaria in the past.

摘要

对来自意大利撒丁岛的1218人进行了Gm和Km标记检测；10人未进行Gm检测，仅401人进行了Am标记分型。撒丁岛人群独特的基因构成通过其Gm同种异型得到证实。他们与意大利大陆对照人群（费拉拉）的差异表明，他们与中东和非洲有过古代接触。在单倍型Gm f;n;bsc5的显著存在中也可能找到这种接触的迹象，该单倍型此前未在人类群体中发现。在高地和低地地区观察到G2m(n)同种异型存在显著差异。如果得到证实，这可能表明与γ2链的CH2区域相关的适应性压力，可能是由于过去的地方性疟疾。

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