通过δ2-噻唑啉高效微波辅助合成光学活性双环2-吡啶酮
Efficient microwave assisted synthesis of optically active bicyclic 2-pyridinones via delta2-thiazolines.
作者信息
Emtenäs Hans, Taflin Camilla, Almqvist Fredrik
机构信息
Organic Chemistry, Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden.
出版信息
Mol Divers. 2003;7(2-4):165-9. doi: 10.1023/b:modi.0000006800.46154.99.
Abstract
A new efficient synthesis of optically active bicyclic 2-pyridiones has been developed using microwave irradiation. The synthesis is a two-step procedure via delta2-thiazolines, which only requires a 3 + 2 min reaction time compared to 2 days when using conventional heating. The optimized conditions proved to be suitable for the synthesis of a small library in excellent yields and with limited racemizations.
摘要
利用微波辐射开发了一种新的高效合成光学活性双环2-吡啶酮的方法。该合成是通过δ2-噻唑啉的两步过程，与使用传统加热时的2天相比，仅需3 + 2分钟的反应时间。优化后的条件被证明适用于以优异的产率和有限的外消旋化合成一个小型文库。
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